Detalhe da pesquisa
1.
Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes - Part 2.
Bioorg Med Chem Lett
; 53: 128416, 2021 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34710625
2.
Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype.
Bioorg Med Chem Lett
; 30(3): 126812, 2020 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31784320
3.
Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes.
Bioorg Med Chem Lett
; 30(4): 126811, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31787491
4.
Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.
Bioorg Med Chem Lett
; 29(21): 126678, 2019 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31537424
5.
Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.
Platelets
; 30(1): 126-135, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30560697
6.
Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.
Mol Pharmacol
; 91(1): 39-47, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27784794
7.
Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.
Bioorg Med Chem Lett
; 26(15): 3499-502, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27342750
8.
Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.
Bioorg Med Chem Lett
; 26(15): 3503-7, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27342751
9.
Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists.
Bioorg Med Chem Lett
; 26(23): 5757-5764, 2016 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28327307
10.
Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.
Bioorg Med Chem Lett
; 26(22): 5481-5486, 2016 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27777004
11.
Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.
Bioorg Med Chem Lett
; 26(10): 2481-2488, 2016 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27080176
12.
Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.
Matrix Biol
; 57-58: 258-271, 2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27915093
13.
Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues.
Org Lett
; 18(23): 6038-6041, 2016 12 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27934359
14.
Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin.
J Med Chem
; 59(16): 7690-5, 2016 08 25.
Artigo
Inglês
| MEDLINE | ID: mdl-27482618