Detalhe da pesquisa
1.
Dengue virus serotypic replacement of NS3 protease or helicase domain causes chimeric viral attenuation but can be recovered by a compensated mutation at helicase domain or NS2B, respectively.
J Virol
; 97(8): e0085423, 2023 08 31.
Artigo
Inglês
| MEDLINE | ID: mdl-37555662
2.
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Proc Natl Acad Sci U S A
; 117(49): 31365-31375, 2020 12 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33229545
3.
Infection of Aedes albopictus Mosquito C6/36 Cells with the wMelpop Strain of Wolbachia Modulates Dengue Virus-Induced Host Cellular Transcripts and Induces Critical Sequence Alterations in the Dengue Viral Genome.
J Virol
; 93(15)2019 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31092581
4.
Serotype-specific interactions among functional domains of dengue virus 2 nonstructural proteins (NS) 5 and NS3 are crucial for viral RNA replication.
J Biol Chem
; 292(23): 9465-9479, 2017 06 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28396347
5.
Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface.
PLoS Pathog
; 12(2): e1005451, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26895240
6.
Flavivirus RNA synthesis in vitro.
Methods
; 91: 20-34, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26272247
7.
Substitution of NS5 N-terminal domain of dengue virus type 2 RNA with type 4 domain caused impaired replication and emergence of adaptive mutants with enhanced fitness.
J Biol Chem
; 289(32): 22385-400, 2014 Aug 08.
Artigo
Inglês
| MEDLINE | ID: mdl-24904061
8.
Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome.
Nucleic Acids Res
; 41(9): 5075-89, 2013 May.
Artigo
Inglês
| MEDLINE | ID: mdl-23531545
9.
The Role of Furin in the Pathogenesis of COVID-19-Associated Neurological Disorders.
Life (Basel)
; 14(2)2024 Feb 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38398788
10.
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases.
Bioorg Med Chem
; 21(1): 102-13, 2013 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23211969
11.
Flavivirus proteases: The viral Achilles heel to prevent future pandemics.
Antiviral Res
; 210: 105516, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36586467
12.
Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.
Bioorg Med Chem
; 20(3): 1213-21, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22249124
13.
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold.
Bioorg Med Chem
; 20(13): 4140-8, 2012 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22632792
14.
Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase.
Nat Commun
; 12(1): 2530, 2021 05 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33953197
15.
Host gene expression modulated by Zika virus infection of human-293 cells.
Virology
; 552: 32-42, 2021 01 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33059318
16.
Genome 3'-end repair in dengue virus type 2.
RNA
; 14(12): 2645-56, 2008 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-18974278
17.
Effects of detergents on the West Nile virus protease activity.
Bioorg Med Chem
; 17(9): 3278-82, 2009 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19369080
18.
Inhibition of dengue virus by curcuminoids.
Antiviral Res
; 162: 71-78, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30529358
19.
Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus.
Antiviral Res
; 137: 141-150, 2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27889529
20.
High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease.
Antiviral Res
; 134: 6-16, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27539384