Detalhe da pesquisa
1.
Regioselective aliphatic C-H functionalization using frustrated radical pairs.
Nature
; 619(7970): 514-520, 2023 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-37407819
2.
Exploring Electrochemical C(sp3)-H Oxidation for the Late-Stage Methylation of Complex Molecules.
J Am Chem Soc
; 144(3): 1187-1197, 2022 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-35015533
3.
Switching on elusive organometallic mechanisms with photoredox catalysis.
Nature
; 524(7565): 330-4, 2015 Aug 20.
Artigo
Inglês
| MEDLINE | ID: mdl-26266976
4.
Direct ß-alkylation of aldehydes via photoredox organocatalysis.
J Am Chem Soc
; 136(19): 6858-61, 2014 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-24754456
5.
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
J Med Chem
; 67(5): 3287-3306, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38431835
6.
The Direct Decarboxylative N-Alkylation of Azoles, Sulfonamides, Ureas, and Carbamates with Carboxylic Acids via Photoredox Catalysis.
Org Lett
; 23(24): 9563-9568, 2021 12 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34881895
7.
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.
ACS Med Chem Lett
; 12(8): 1230-1237, 2021 Aug 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34413952
8.
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
J Med Chem
; 64(7): 3843-3869, 2021 04 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33749283
9.
Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015-2019).
Expert Opin Ther Pat
; 30(9): 643-657, 2020 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-32686526
10.
Visible-Light Photocatalysis as an Enabling Technology for Drug Discovery: A Paradigm Shift for Chemical Reactivity.
ACS Med Chem Lett
; 11(11): 2120-2130, 2020 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33214820
11.
Simple strategy towards amide bioisosteres.
Nat Chem
; 14(2): 120-121, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35087219
12.
Native functionality in triple catalytic cross-coupling: sp³ C-H bonds as latent nucleophiles.
Science
; 352(6291): 1304-8, 2016 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27127237
13.
O-H hydrogen bonding promotes H-atom transfer from α C-H bonds for C-alkylation of alcohols.
Science
; 349(6255): 1532-6, 2015 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26316601
14.
Dual catalysis. Merging photoredox with nickel catalysis: coupling of α-carboxyl sp³-carbons with aryl halides.
Science
; 345(6195): 437-40, 2014 Jul 25.
Artigo
Inglês
| MEDLINE | ID: mdl-24903563