Detalhe da pesquisa
1.
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation.
Nature
; 458(7242): 1180-4, 2009 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-19407801
2.
Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr-/-.Leiden mice.
Heliyon
; 9(3): e13985, 2023 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-36915476
3.
Glucan particles for selective delivery of siRNA to phagocytic cells in mice.
Biochem J
; 436(2): 351-62, 2011 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21418037
4.
Serine catabolism generates liver NADPH and supports hepatic lipogenesis.
Nat Metab
; 3(12): 1608-1620, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34845393
5.
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction.
Mol Metab
; 48: 101196, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33667726
6.
Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes.
J Biol Chem
; 284(25): 17082-17091, 2009 Jun 19.
Artigo
Inglês
| MEDLINE | ID: mdl-19321447
7.
Finding the Sweet Spot: Parsing Tissue-Specific Contributions of Fructose Metabolism.
Cell Metab
; 32(1): 6-8, 2020 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32640246
8.
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J Med Chem
; 63(22): 13546-13560, 2020 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32910646
9.
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Sci Transl Med
; 11(492)2019 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31092695
10.
The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.
Cell Metab
; 27(2): 351-361.e3, 2018 02 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29414685
11.
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J Med Chem
; 60(18): 7835-7849, 2017 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28853885
12.
Dexamethasone suppresses phospholipase C activation and insulin secretion from isolated rat islets.
Metabolism
; 55(1): 35-42, 2006 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-16324917
13.
RNAi-based therapeutic strategies for metabolic disease.
Nat Rev Endocrinol
; 7(8): 473-84, 2011 Apr 19.
Artigo
Inglês
| MEDLINE | ID: mdl-21502982
14.
Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.
J Biol Chem
; 282(27): 19302-12, 2007 Jul 06.
Artigo
Inglês
| MEDLINE | ID: mdl-17500068
15.
Effects of prior 5-hydroxytryptamine exposure on rat islet insulin secretory and phospholipase C responses.
Endocrine
; 23(1): 11-6, 2004 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-15034191
16.
Effects of muscarinic receptor type 3 knockout on mouse islet secretory responses.
Biochem Biophys Res Commun
; 315(4): 872-6, 2004 Mar 19.
Artigo
Inglês
| MEDLINE | ID: mdl-14985093