Detalhe da pesquisa
1.
Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells.
J Biol Chem
; 299(9): 105156, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37572852
2.
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Cell
; 136(5): 839-851, 2009 Mar 06.
Artigo
Inglês
| MEDLINE | ID: mdl-19217150
3.
Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia.
Mol Cancer
; 13: 28, 2014 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24517586
4.
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
EMBO Rep
; 13(3): 251-7, 2012 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22310300
5.
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep
; 12(5): 463-9, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21460794
6.
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
Org Biomol Chem
; 11(5): 732-745, 2013 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23151668
7.
Orelabrutinib for the treatment of relapsed or refractory MCL: a phase 1/2, open-label, multicenter, single-arm study.
Blood Adv
; 7(16): 4349-4357, 2023 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-37078706
8.
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
J Biol Chem
; 286(15): 13041-51, 2011 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21335549
9.
Evaluation of orelabrutinib monotherapy in patients with relapsed or refractory Waldenström's macroglobulinemia in a single-arm, multicenter, open-label, phase 2 study.
EClinicalMedicine
; 52: 101682, 2022 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-36313145
10.
[Clinical observation of different surgical methods for metaphyseal sequelae of ulna].
Zhongguo Gu Shang
; 34(7): 636-40, 2021 Jul 25.
Artigo
Chinês
| MEDLINE | ID: mdl-34318639
11.
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.
Elife
; 82019 09 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31500697
12.
Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
Biochem J
; 397(1): 179-86, 2006 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16509823
13.
Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.
Angew Chem Int Ed Engl
; 51(27): 6672-5, 2012 Jul 02.
Artigo
Inglês
| MEDLINE | ID: mdl-22639232
14.
Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases.
Circ Res
; 95(2): 162-9, 2004 Jul 23.
Artigo
Inglês
| MEDLINE | ID: mdl-15192023
15.
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun
; 7: 12673, 2016 08 26.
Artigo
Inglês
| MEDLINE | ID: mdl-27561929
16.
Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.
FASEB J
; 18(9): 1028-30, 2004 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15084514
17.
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.
PLoS One
; 10(8): e0134645, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26262842
18.
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
PLoS One
; 10(7): e0132004, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26147748
19.
Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
FEBS Lett
; 576(1-2): 145-50, 2004 Oct 08.
Artigo
Inglês
| MEDLINE | ID: mdl-15474027
20.
The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
FEBS Lett
; 570(1-3): 166-70, 2004 Jul 16.
Artigo
Inglês
| MEDLINE | ID: mdl-15251459