Detalhe da pesquisa
1.
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Proc Natl Acad Sci U S A
; 121(1): e2307086120, 2024 Jan 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38147543
2.
The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.
Bioorg Med Chem Lett
; 26(13): 3109-3114, 2016 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27189675
3.
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
Bioorg Med Chem Lett
; 22(24): 7357-62, 2012 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23141911
4.
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J Med Chem
; 65(21): 14326-14336, 2022 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36314537
5.
Novel Reagent Space: Identifying Unorderable but Readily Synthesizable Building Blocks.
ACS Med Chem Lett
; 12(11): 1853-1860, 2021 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34795876
6.
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
ACS Med Chem Lett
; 12(5): 782-790, 2021 May 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34055226
7.
Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease.
J Med Chem
; 63(6): 2915-2929, 2020 03 26.
Artigo
Inglês
| MEDLINE | ID: mdl-32134643
8.
Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.
J Med Chem
; 58(18): 7119-27, 2015 Sep 24.
Artigo
Inglês
| MEDLINE | ID: mdl-25993395
9.
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.
ACS Med Chem Lett
; 6(12): 1204-8, 2015 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26713105
10.
Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.
ACS Med Chem Lett
; 3(10): 823-7, 2012 Oct 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24900385
11.
Yatakemycin: total synthesis, DNA alkylation, and biological properties.
Nat Prod Rep
; 25(2): 220-6, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18389136
12.
Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.
J Am Chem Soc
; 129(35): 10858-69, 2007 Sep 05.
Artigo
Inglês
| MEDLINE | ID: mdl-17691783
13.
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
J Am Chem Soc
; 129(45): 14092-9, 2007 Nov 14.
Artigo
Inglês
| MEDLINE | ID: mdl-17948994
14.
Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.
J Am Chem Soc
; 128(49): 15683-96, 2006 Dec 13.
Artigo
Inglês
| MEDLINE | ID: mdl-17147378
15.
Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin.
J Am Chem Soc
; 126(27): 8396-8, 2004 Jul 14.
Artigo
Inglês
| MEDLINE | ID: mdl-15237994
16.
Ruthenium-mediated cycloaromatization of acyclic enediynes and dienynes at ambient temperature.
J Am Chem Soc
; 124(14): 3506-7, 2002 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-11929230