Detalhe da pesquisa
1.
Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis.
Breast Cancer Res Treat
; 164(3): 581-591, 2017 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-28493046
2.
Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.
Mol Cancer Ther
; 7(9): 2599-608, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18790743
3.
Oncogenic BRAF is required for tumor growth and maintenance in melanoma models.
Cancer Res
; 66(2): 999-1006, 2006 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16424035
4.
Regulation of ERK3/MAPK6 expression by BRAF.
Int J Oncol
; 29(4): 839-49, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16964379
5.
Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity.
Mol Cancer Ther
; 14(10): 2270-8, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26269606
6.
MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer.
Clin Cancer Res
; 20(24): 6324-35, 2014 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25326231
7.
Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering.
J Med Chem
; 57(19): 7890-9, 2014 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25191794
8.
Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer.
Sci Transl Med
; 5(171): 171ra18, 2013 Feb 06.
Artigo
Inglês
| MEDLINE | ID: mdl-23390248
9.
Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma.
Cancer Chemother Pharmacol
; 69(4): 1071-8, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22203368
10.
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.
Nat Biotechnol
; 30(2): 184-9, 2012 Jan 22.
Artigo
Inglês
| MEDLINE | ID: mdl-22267010
11.
An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma.
Clin Cancer Res
; 17(5): 965-75, 2011 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21245091
12.
Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.
Cancer Res
; 69(7): 3042-51, 2009 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19276360
13.
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
J Clin Invest
; 119(5): 1216-29, 2009 May.
Artigo
Inglês
| MEDLINE | ID: mdl-19381019
14.
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
J Cell Biol
; 183(1): 101-16, 2008 Oct 06.
Artigo
Inglês
| MEDLINE | ID: mdl-18838554
15.
Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.
Dev Dyn
; 233(1): 130-41, 2005 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15765504
16.
Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF.
Biochem Biophys Res Commun
; 326(3): 624-31, 2005 Jan 21.
Artigo
Inglês
| MEDLINE | ID: mdl-15596145
17.
Hyaluronan and morphogenesis.
Birth Defects Res C Embryo Today
; 72(1): 89-108, 2004 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-15054906
18.
Investigation of hyaluronan function in the mouse through targeted mutagenesis.
Glycoconj J
; 19(4-5): 341-5, 2002.
Artigo
Inglês
| MEDLINE | ID: mdl-12975614