Detalhe da pesquisa
1.
Computational design of ligand-binding proteins with high affinity and selectivity.
Nature
; 501(7466): 212-216, 2013 Sep 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24005320
2.
Improved Free-Energy Landscape Quantification Illustrated with a Computationally Designed Protein-Ligand Interaction.
Chemphyschem
; 19(1): 19-23, 2018 01 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29069529
3.
Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring.
Nat Chem Biol
; 10(7): 598-603, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24907901
4.
CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge.
J Chem Inf Model
; 56(6): 1022-31, 2016 06 27.
Artigo
Inglês
| MEDLINE | ID: mdl-26419257
5.
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design.
J Am Chem Soc
; 137(32): 10414-9, 2015 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-26226626
6.
Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
PLoS One
; 18(6): e0285971, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37267316
7.
VERITAS: Harnessing the power of nomenclature in biologic discovery.
MAbs
; 15(1): 2207232, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37162235
8.
Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features.
MAbs
; 15(1): 2163584, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36683173
9.
Autonomous IL-36R signaling in neutrophils activates potent antitumor effector functions.
J Clin Invest
; 133(12)2023 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37317970
10.
Dioxygen activation in soluble methane monooxygenase.
Acc Chem Res
; 44(4): 280-8, 2011 Apr 19.
Artigo
Inglês
| MEDLINE | ID: mdl-21391602
11.
Multiple roles of component proteins in bacterial multicomponent monooxygenases: phenol hydroxylase and toluene/o-xylene monooxygenase from Pseudomonas sp. OX1.
Biochemistry
; 50(11): 1788-98, 2011 Mar 22.
Artigo
Inglês
| MEDLINE | ID: mdl-21366224
12.
Oxidation reactions performed by soluble methane monooxygenase hydroxylase intermediates H(peroxo) and Q proceed by distinct mechanisms.
Biochemistry
; 49(36): 7902-12, 2010 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-20681546
13.
Characterization of iron dinitrosyl species formed in the reaction of nitric oxide with a biological Rieske center.
J Am Chem Soc
; 132(51): 18168-76, 2010 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-21133361
14.
Identification of protein-bound dinitrosyl iron complexes by nuclear resonance vibrational spectroscopy.
J Am Chem Soc
; 132(20): 6914-6, 2010 May 26.
Artigo
Inglês
| MEDLINE | ID: mdl-20429508
15.
Revisiting the mechanism of dioxygen activation in soluble methane monooxygenase from M. capsulatus (Bath): evidence for a multi-step, proton-dependent reaction pathway.
Biochemistry
; 48(51): 12145-58, 2009 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-19921958
16.
Engineered Biosensors from Dimeric Ligand-Binding Domains.
ACS Synth Biol
; 7(10): 2457-2467, 2018 10 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30204430
17.
Computational Design of Ligand Binding Proteins.
Methods Mol Biol
; 1529: 363-373, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-27914062
18.
Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.
MAbs
; 9(5): 854-873, 2017 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28379093
19.
Improving Binding Affinity and Selectivity of Computationally Designed Ligand-Binding Proteins Using Experiments.
Methods Mol Biol
; 1414: 155-71, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27094290
20.
A general strategy to construct small molecule biosensors in eukaryotes.
Elife
; 42015 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-26714111