Detalhe da pesquisa
1.
Induction or protection of limbic seizures in mice by mGluR subtype selective agonists.
Neuropharmacology
; 34(8): 1063-7, 1995 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-8532155
2.
Antidepressant-like actions of an AMPA receptor potentiator (LY392098).
Neuropharmacology
; 40(8): 1028-33, 2001 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-11406194
3.
Blockade of the second messenger functions of the glutamate metabotropic receptor is associated with degenerative changes in the retina and brain of immature rodents.
Neuropharmacology
; 34(8): 1069-79, 1995 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-8532156
4.
LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats.
Neuropharmacology
; 36(11-12): 1511-6, 1997.
Artigo
Inglês
| MEDLINE | ID: mdl-9517421
5.
In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.
Neuropharmacology
; 34(9): 1159-68, 1995 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-8532186
6.
(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.
J Med Chem
; 38(25): 4885-90, 1995 Dec 08.
Artigo
Inglês
| MEDLINE | ID: mdl-8523401
7.
2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.
J Med Chem
; 41(3): 358-78, 1998 Jan 29.
Artigo
Inglês
| MEDLINE | ID: mdl-9464367
8.
Synthesis of a series of aryl kainic acid analogs and evaluation in cells stably expressing the kainate receptor humGluR6.
J Med Chem
; 39(19): 3617-24, 1996 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-8809152
9.
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.
J Med Chem
; 39(15): 2990-3000, 1996 Jul 19.
Artigo
Inglês
| MEDLINE | ID: mdl-8709133
10.
Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties.
J Med Chem
; 40(4): 528-37, 1997 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-9046344
11.
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.
J Med Chem
; 42(6): 1027-40, 1999 Mar 25.
Artigo
Inglês
| MEDLINE | ID: mdl-10090786
12.
Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity.
Psychopharmacology (Berl)
; 113(2): 205-10, 1993.
Artigo
Inglês
| MEDLINE | ID: mdl-7855182
13.
Neonatal exposure to D,L-2-amino-3-phosphonopropionate (D,L-AP3) produces lesions in the eye and optic nerve of adult rats.
Brain Res Dev Brain Res
; 75(2): 223-33, 1993 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-8261613
14.
Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists.
Neurosci Lett
; 162(1-2): 12-6, 1993 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-8121613
15.
Some effects of pimozide on nondeprived rats' lever pressing maintained by a sucrose reward in an anhedonia paradigm.
Pharmacol Biochem Behav
; 27(1): 67-72, 1987 May.
Artigo
Inglês
| MEDLINE | ID: mdl-3615548
16.
Developmental toxicity of the dopamine agonist pergolide mesylate in CD-1 mice. II: Perinatal and postnatal exposure.
Neurotoxicol Teratol
; 13(3): 297-306, 1991.
Artigo
Inglês
| MEDLINE | ID: mdl-1886539
17.
Developmental toxicity of the dopamine agonist pergolide mesylate in CD-1 mice. I: Gestational exposure.
Neurotoxicol Teratol
; 13(3): 283-95, 1991.
Artigo
Inglês
| MEDLINE | ID: mdl-1886538
18.
Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors.
J Med Chem
; 43(23): 4354-8, 2000 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-11087558
19.
Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice.
Ann N Y Acad Sci
; 765: 230-5; discussion 248, 1995 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-7486609
20.
Developmental toxicity of gemcitabine, an antimetabolite oncolytic, administered during gestation to CD-1 mice.
Teratology
; 48(4): 365-81, 1993 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-8278936