Detalhe da pesquisa
1.
Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples.
Anal Chem
; 91(6): 3790-3794, 2019 03 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30835099
2.
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.
J Med Chem
; 65(9): 6940-6952, 2022 05 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35471939
3.
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib.
Mol Cancer Ther
; 20(2): 238-249, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33273059
4.
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C.
J Med Chem
; 63(9): 4468-4483, 2020 05 14.
Artigo
Inglês
| MEDLINE | ID: mdl-32023060
5.
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
J Med Chem
; 62(24): 11004-11018, 2019 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31710489
6.
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J Med Chem
; 60(8): 3438-3450, 2017 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28376306
7.
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J Med Chem
; 59(24): 11120-11137, 2016 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28002956
8.
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Cancer Res
; 76(11): 3307-18, 2016 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27020862
9.
A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERDs).
J Biomol Screen
; 20(6): 748-59, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25851036
10.
Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.
J Med Chem
; 58(11): 4790-801, 2015 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25977981
11.
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J Med Chem
; 58(20): 8128-40, 2015 Oct 22.
Artigo
Inglês
| MEDLINE | ID: mdl-26407012
12.
Development of a high-throughput fluorescence polarization DNA cleavage assay for the identification of FEN1 inhibitors.
J Biomol Screen
; 18(5): 567-75, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23427045