RESUMO
The most common genetic defect associated with deep vein thrombosis (DVT) is a mutation in the Factor V gene (G1691A), known as Factor V Leiden (FVL). We investigated the genotypes for FVL in 571 individuals in Venezuela: 208 patients with DVT, 175 patients with acute myocardial infarction, 54 patients with stroke, and 134 control subjects. Our results showed in the population analyzed here that the FVL was associated with a fourfold increase in the risk for DVT (odds ratio, 4.24; 95% confidence interval, 1.35-14.79); particularly, women carriers showed a 6.5-fold increase in the risk for DVT. No relation was observed between the presence of FVL and the risk for acute myocardial infarction or stroke. In conclusion, a clear association between the FVL mutation and DVT was observed in the population analyzed in Venezuela. These results are in agreement with those found in other populations with different ethnic backgrounds.
Assuntos
Fator V/genética , Infarto do Miocárdio/genética , Acidente Vascular Cerebral/genética , Trombose Venosa/genética , Idoso , Estudos de Casos e Controles , Feminino , Predisposição Genética para Doença , Variação Genética , Humanos , Masculino , Pessoa de Meia-Idade , Mutação , Fatores de Risco , VenezuelaRESUMO
Se reporta el caso de una paciente de 63 años de edad quien consultó por presentar equimosis y hematomas espontáneos en antebrazos y piernas, y epistaxis, encontrándose un anticoagulante lúpico positivo y un inhibidor del Factor VIII