CausalTAB: the PSI-MITAB 2.8 updated format for signalling data representation and dissemination.

MOTIVATION: Combining multiple layers of information underlying biological complexity into a structured framework represent a challenge in systems biology. A key task is the formalization of such information in models describing how biological entities interact to mediate the response to external and internal signals. Several databases with signalling information, focus on capturing, organizing and displaying signalling interactions by representing them as binary, causal relationships between biological entities. The curation efforts that build these individual databases demand a concerted effort to ensure interoperability among resources. RESULTS: Aware of the enormous benefits of standardization efforts in the molecular interaction research field, representatives of the signalling network community agreed to extend the PSI-MI controlled vocabulary to include additional terms representing aspects of causal interactions. Here, we present a common standard for the representation and dissemination of signalling information: the PSI Causal Interaction tabular format (CausalTAB) which is an extension of the existing PSI-MI tab-delimited format, now designated PSI-MITAB 2.8. We define the new term 'causal interaction', and related child terms, which are children of the PSI-MI 'molecular interaction' term. The new vocabulary terms in this extended PSI-MI format will enable systems biologists to model large-scale signalling networks more precisely and with higher coverage than before. AVAILABILITY AND IMPLEMENTATION: PSI-MITAB 2.8 format and the new reference implementation of PSICQUIC are available online (https://psicquic.github.io/ and https://psicquic.github.io/MITAB28Format.html). SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Evaluation d'une campagne de vaccination . Cas specifique : la campagne de vaccination contre la fievre jaune a Abidjan-Anyama-Bingerville-Songon Cote d'Ivoire (du 21 septembre au 02 octobre 2001)

OBJECTIF : Notre etude avait pour objectif d'evaluer la campagne de masse contre la fievre jaune qui a lieu a Abidjan et ses banlieues (Anyama-Bingerville-Songon) du 21/09 au 02/10/2001.METHODE : Il s'agit d'une etude retrospective a partir des donnees de la campagne.RESULTATS*La couverture vaccinale a ete de 91;33pour cent; tres satisfaisante.*Les MAPI rapportees ont ete tres peu en nombre (85 cas pour 2610944 vaccines) et benignes.*La securite vaccinale a ete tres bonne.*2605 personnes ont ete mobilisees dont 1.009 professionnels de la sante*Le cout global de la campagne a ete de 1.440.899.645 Fcfa.*Le cout de la vaccination anti-amarile a ete d'environ 522 Fcfa.CONCLUSION : Cette campagne de vaccination contre' la fievre jaune a ete la plus importante qu'a connu la Cote d'Ivoire tant par la population cible que sur le plan materiel et humain. Elle a permis de mettre en place des equipements qui pourront servir en appoint dans les campagnes a venir