Detalhe da pesquisa
1.
Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis.
Nature
; 602(7896): 343-348, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35110734
2.
ThnL, a B12-dependent radical S-adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis.
Proc Natl Acad Sci U S A
; 119(34): e2206494119, 2022 08 23.
Artigo
Inglês
| MEDLINE | ID: mdl-35969793
3.
Competing off-loading mechanisms of meropenem from an l,d-transpeptidase reduce antibiotic effectiveness.
Proc Natl Acad Sci U S A
; 118(27)2021 07 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34187885
4.
Evolutionary and functional analysis of an NRPS condensation domain integrates ß-lactam, á´ -amino acid, and dehydroamino acid synthesis.
Proc Natl Acad Sci U S A
; 118(17)2021 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-33893237
5.
Normal and Aberrant Methyltransferase Activities Give Insights into the Final Steps of Dynemicin A Biosynthesis.
J Am Chem Soc
; 145(23): 12935-12947, 2023 06 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37276497
6.
Colorimetric Determination of Adenylation Domain Activity in Nonribosomal Peptide Synthetases by Using Chrome Azurol S.
Chembiochem
; 24(5): e202200668, 2023 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36511946
7.
Sea Urchin Polyketide Synthase SpPks1 Produces the Naphthalene Precursor to Echinoderm Pigments.
J Am Chem Soc
; 144(21): 9363-9371, 2022 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35588530
8.
T405, a New Penem, Exhibits In Vivo Efficacy against M. abscessus and Synergy with ß-Lactams Imipenem and Cefditoren.
Antimicrob Agents Chemother
; 66(6): e0053622, 2022 06 21.
Artigo
Inglês
| MEDLINE | ID: mdl-35638855
9.
ß-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.
Nature
; 520(7547): 383-7, 2015 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-25624104
10.
Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genus Colletotrichum.
Proc Natl Acad Sci U S A
; 115(24): E5459-E5466, 2018 06 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29844193
11.
C-N-Coupled Metabolites Yield Insights into Dynemicin A Biosynthesis.
Chembiochem
; 21(15): 2137-2142, 2020 08 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32198800
12.
Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase.
Nat Chem Biol
; 14(1): 5-7, 2018 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-29155429
13.
The structural organization of substrate loading in iterative polyketide synthases.
Nat Chem Biol
; 14(5): 474-479, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29610486
14.
Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc Natl Acad Sci U S A
; 114(21): E4142-E4148, 2017 05 23.
Artigo
Inglês
| MEDLINE | ID: mdl-28484029
15.
Non-classical transpeptidases yield insight into new antibacterials.
Nat Chem Biol
; 13(1): 54-61, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27820797
16.
Mechanism of Integrated ß-Lactam Formation by a Nonribosomal Peptide Synthetase during Antibiotic Synthesis.
Biochemistry
; 57(24): 3353-3358, 2018 06 19.
Artigo
Inglês
| MEDLINE | ID: mdl-29701951
17.
The architectures of iterative type I PKS and FAS.
Nat Prod Rep
; 35(10): 1046-1069, 2018 10 17.
Artigo
Inglês
| MEDLINE | ID: mdl-30137093
18.
Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis.
Proc Natl Acad Sci U S A
; 112(33): 10354-8, 2015 Aug 18.
Artigo
Inglês
| MEDLINE | ID: mdl-26240322
19.
Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis.
Angew Chem Int Ed Engl
; 57(20): 5650-5654, 2018 05 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29512267
20.
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.
BMC Biochem
; 18(1): 8, 2017 05 25.
Artigo
Inglês
| MEDLINE | ID: mdl-28545389