Detalhe da pesquisa
1.
A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice.
Cancer Immunol Immunother
; 67(2): 247-259, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29067496
2.
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
Cell Chem Biol
; 30(10): 1191-1210.e20, 2023 10 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37557181
3.
Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.
Mol Cancer Ther
; 17(12): 2530-2542, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30232146
4.
Combination of 4-1BB agonist and PD-1 antagonist promotes antitumor effector/memory CD8 T cells in a poorly immunogenic tumor model.
Cancer Immunol Res
; 3(2): 149-60, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25387892
5.
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Cancer Cell
; 28(1): 70-81, 2015 Jul 13.
Artigo
Inglês
| MEDLINE | ID: mdl-26144315
6.
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
J Med Chem
; 57(4): 1170-87, 2014 Feb 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24432909
7.
Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell line.
Front Med
; 7(4): 462-76, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23820871
8.
Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.
PLoS One
; 8(6): e67258, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23826249
9.
Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621.
MAbs
; 4(6): 710-23, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-23007574
10.
PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.
Mol Cancer Ther
; 9(4): 883-94, 2010 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-20354118