Detalhe da pesquisa
1.
New boronate drugs and evolving NDM-mediated beta-lactam resistance.
Antimicrob Agents Chemother
; 67(9): e0057923, 2023 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37650617
2.
In vitro potency of xeruborbactam in combination with multiple ß-lactam antibiotics in comparison with other ß-lactam/ß-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum ß-lactamase-producing Enterobacterales.
Antimicrob Agents Chemother
; 67(11): e0044023, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37800963
3.
The Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 Restores the Potency of Multiple Oral Beta-Lactam Antibiotics against Beta-Lactamase-Producing Strains of Resistant Enterobacterales.
Antimicrob Agents Chemother
; 66(2): e0216821, 2022 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34902261
4.
Intrinsic Antibacterial Activity of Xeruborbactam In Vitro: Assessing Spectrum and Mode of Action.
Antimicrob Agents Chemother
; 66(10): e0087922, 2022 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36102663
5.
In Vitro Activity of the Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 65(6)2021 05 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33782010
6.
Potency of Vaborbactam Is Less Affected than That of Avibactam in Strains Producing KPC-2 Mutations That Confer Resistance to Ceftazidime-Avibactam.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32015028
7.
Biochemical Activity of Vaborbactam.
Antimicrob Agents Chemother
; 64(2)2020 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31712199
8.
Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32152086
9.
Structural Basis and Binding Kinetics of Vaborbactam in Class A ß-Lactamase Inhibition.
Antimicrob Agents Chemother
; 64(10)2020 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32778546
10.
In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii.
Antimicrob Agents Chemother
; 64(11)2020 10 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32868334
11.
Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32229489
12.
Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32229498
13.
Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28848018
14.
Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28739787
15.
QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics.
Front Microbiol
; 12: 697180, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34290688
16.
Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa.
mBio
; 12(1)2021 01 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33468691
17.
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-ß-lactamases.
J Med Chem
; 63(14): 7491-7507, 2020 07 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32150407
18.
Discovery of a Cyclic Boronic Acid ß-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
J Med Chem
; 58(9): 3682-92, 2015 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-25782055