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1.
Int J Immunogenet ; 36(1): 15-9, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19055603

RESUMO

NRAMP1 gene has multiple pleiotropic effects on macrophage activation pathways. These pleiotropic effects may increase resistance to infections such as tuberculosis (TB), but may also lead to susceptibility of autoimmune diseases such as rheumatoid arthritis (RA). It has been hypothesized that allele 3 would be associated with autoimmune diseases, whereas allele 2 would be associated with infectious diseases, and genetic factors that enhanced survival in the epidemics of TB might have led to susceptibility for the development of RA. We analysed four NRAMP1 gene polymorphisms including 5' promoter (GT)(n) (rs34448891), INT4 (469 + 14G/C) (rs3731865), 3'UTR (1729 + 55del4) (rs17235416) and D543N (codon 543, Asp to Asn) (rs17235409) in 112 patients with TB, 98 patients with RA, 80 healthy controls for TB and 122 healthy controls for RA using ARMS-PCR and PCR-RFLP. We found a significant association between INT4 and RA (P = 0.004, odds ratio: 2.06, 95% CI: 1.24-3.41), but no significant differences between 5' promoter, D543N, 3'UTR polymorphisms and RA. There were no associations between NRAMP1 gene polymorphisms and TB. Similarly, no significant differences were observed between NRAMP1 polymorphisms and rheumatoid factor positivity and erosive disease in RA and localization of TB. INT4 polymorphism may be associated with RA in Turkish patients.


Assuntos
Artrite Reumatoide/genética , Doenças Autoimunes/genética , Proteínas de Transporte de Cátions/genética , Frequência do Gene/genética , Tuberculose/genética , Adulto , Alelos , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético , Fatores de Risco
2.
Monaldi Arch Chest Dis ; 67(4): 238-40, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18309703

RESUMO

A 31-year-old woman presented with a cough, pain on the left side on deep inspiration, dyspnea, and fever. A chest x-ray showed pneumonic infiltration of the left middle and lower lung and decreased left hemithorax volume. A computed tomography (CT) revealed an occlusion of the left main bronchus by an intraluminal tumour. Bronchoscopic biopsy specimens suggested an endobronchial hamartoma. Therefore, we resected the tumour endobronchially using a bronchoscopic electrosurgical snare and argon plasma coagulation.


Assuntos
Broncopatias/cirurgia , Broncoscopia , Eletrocirurgia , Hamartoma/cirurgia , Fotocoagulação a Laser , Adulto , Broncopatias/patologia , Feminino , Hamartoma/patologia , Humanos
3.
Monaldi Arch Chest Dis ; 63(2): 101-7, 2005 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16128225

RESUMO

BACKGROUND: Residual pleural thickening (RPT) still occurs in most patients with tuberculosis pleurisy despite advances in the treatment of tuberculosis. The aim of this study was to evaluate the significance of RPT in tuberculosis pleurisy with the patients clinical findings, biochemical and microbiological properties of pleural effusion and with the total adenosine deaminase (ADA) and isoenzymes levels. METHODS: 121 tuberculosis pleurisy patients were evaluated retrospectively. According to posteroanterior chest x-rays, the 63 (52%) cases with the thickness 2 mm or more in lower lateral hemithorax were grouped as I and the 58 (48%) cases without pleural thickness were grouped as II. The amount of pleural effusion was classified into small, medium or massive according to their chest x-rays. In both groups; sex, age, symptoms score, bacteriological and biochemical tests and ADA levels were recorded. RESULTS: 81 (67%) male and 40 (33%) female, overall 121 patients were enrolled into the study. RPT was found higher in males (p=0.014) and the increase ran parallel with the amount of cigarette smoking (p=0.014). RPT was found to be lower in small effusions (p=0.001). The group with RPT, the serum albumin was found lower (p=0.002), pleural fluid total protein (p=0.047) and the ratio of pleural fluid protein to serum protein (p=0.002) were found higher. In group I, total ADA: 69.5 +/- 38.9 IU/L and ADA2: 41.3 +/- 31.6 IU/L were higher than the cases without RPT (p=0.032, p=0.017, respectively). CONCLUSIONS: We suggest that the immunological mechanisms are effective in the development of pleural thickening.


Assuntos
Adenosina Desaminase/análise , Pleura/diagnóstico por imagem , Tuberculose Pleural/diagnóstico por imagem , Adulto , Proteínas Sanguíneas/análise , Feminino , Humanos , Isoenzimas/análise , Contagem de Linfócitos , Masculino , Mycobacterium tuberculosis/isolamento & purificação , Pleura/enzimologia , Derrame Pleural/química , Derrame Pleural/classificação , Derrame Pleural/microbiologia , Proteínas/análise , Radiografia Torácica , Estudos Retrospectivos , Albumina Sérica/análise , Fatores Sexuais , Fumar , Tuberculose Pleural/sangue , Tuberculose Pleural/enzimologia
5.
J Chemother ; 11(3): 211-4, 1999 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10435684

RESUMO

Acute exacerbations, most of which are due to lower respiratory tract infections, cause great morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD) and most of these are due to lower respiratory tract infections. The aim of this study was to determine the causative organism and the effects of azithromycin, ampicillin sulbactam (sultamicillin), ciprofloxacin and cefaclor monohydrate therapy in COPD. One hundred and six patients with COPD in acute exacerbation were randomized into four groups for empiric antibiotic treatment following lung function tests and sputum examination. The most common strains isolated from sputum were Haemophilus influenzae (30.8%), Streptoccocus pneumoniae (12%) and Moraxella catarrhalis (7.7%). Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.


Assuntos
Anti-Infecciosos/uso terapêutico , Pneumopatias Obstrutivas/tratamento farmacológico , Ampicilina/uso terapêutico , Azitromicina/uso terapêutico , Cefaclor/uso terapêutico , Ciprofloxacina/uso terapêutico , Quimioterapia Combinada/uso terapêutico , Feminino , Humanos , Pneumopatias Obstrutivas/microbiologia , Masculino , Pessoa de Meia-Idade , Sulbactam/uso terapêutico , Resultado do Tratamento
6.
Respir Med ; 103(6): 907-12, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19181507

RESUMO

Epidemiological characteristics of sarcoidosis differ according to geographical distribution. The aim of our study was to disclose epidemiological characteristics in our country. The data was collected from investigators, who sent information on newly-diagnosed patients via internet. In 2 years 198 female and 95 male patients were enrolled to the study (f/m:2.08). Mean age of patients was 44+/-13 years (17-90). Mean age of male patients was 38+/-12 while mean age of female patients was 48+/-13 (p<0.001). 73.4% of patients were nonsmokers (85.4% of females; 48.4% of males; (p<0.001)). About 50% of our 293 patients were housewives. Familial sarcoidosis was found in 3 patients' first degree relatives. Estimated annual incidence of sarcoidosis for Turkey was calculated as 4 per 100,000 person. According to our study, 2/3 of sarcoidosis patients were women; mean age of patients was 45 and the disease began 10 years later in female patients. 80% of patients were nonsmokers; negative relation between sarcoidosis and smoking was evident especially in women. Familial sarcoidosis frequency was lower compared to other studies in the literature. There was no occupational exposure history in our patients. Our incidence rate, is similar with the results of other European studies.


Assuntos
Sarcoidose Pulmonar/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Métodos Epidemiológicos , Feminino , Humanos , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Sarcoidose Pulmonar/diagnóstico , Fumar/epidemiologia , Turquia/epidemiologia , Adulto Jovem
7.
Respiration ; 68(6): 611-4, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11786717

RESUMO

BACKGROUND: The question of which combination of procedures gives the best diagnostic yield following fiberoptic bronchoscopy is controversial. OBJECTIVES: To evaluate the value of various diagnostic techniques following fiberoptic bronchoscopy in the diagnosis of endoscopically visible lung cancer. METHODS: The study included 98 patients found to have endobronchially visible tumor during routine daily bronchoscopy. Endobronchial lesions were classified as mass, submucosal lesion and infiltration. Washings, brushings and forceps biopsies were obtained in all subjects. Transbronchial needle aspirations were performed in 67 of 76 cases with mass or submucosal lesions. RESULTS: Bronchoscopy was diagnostic for cancer in 88 (89.8%) of the 98 patients. Forceps biopsy specimens gave positive result in 82.7% of cases, transbronchial needle aspirates in 68.6%, brushings in 68.4%, and washings in 31.6%. Combination of forceps biopsy and brushing cytology yielded a positive result for lung cancer in 87 patients. The addition of brushings increased the diagnostic yield of bronchoscopy from 82.7% to 88.8% (p < 0.05). Collection of washing specimens in addition to forceps biopsy did not increase the yield of forceps biopsy. Transbronchial needle aspiration gave an additional yield of 1%. CONCLUSIONS: Routine cytological examination of bronchial washings does not increase the yield of forceps biopsy specimens. Transbronchial needle aspiration may give an additional positive yield to forceps biopsy. We conclude that a combination of forceps biopsy and brushing is the best strategy in the diagnosis of bronchoscopically visible lung cancer.


Assuntos
Líquido da Lavagem Broncoalveolar , Broncoscopia , Neoplasias Pulmonares/diagnóstico , Adulto , Idoso , Biópsia , Brônquios/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes
8.
Thorax ; 51(1): 87-9, 1996 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-8658377

RESUMO

BACKGROUND: Whilst intrathoracic lymphadenitis is a characteristic sign of primary tuberculosis in children, its presence without parenchymal lesions in adults is unusual and makes the diagnosis using noninvasive techniques difficult. The diagnostic role of bronchoscopy in adults with intrathoracic tuberculous lymphadenitis is reported. METHODS: Seventeen patients with intrathoracic lymphadenopathy seen during 1993 who had all undergone bronchoscopy and had been found to have tuberculosis in the absence of any parenchymal lung lesions were evaluated retrospectively. RESULTS: Right paratracheal lymphadenopathy was observed on the plain chest radiograph in all the patients. Fifteen of the 17 patients had an endobronchial abnormality and samples taken at bronchoscopy gave a definitive diagnosis in nine (53%) of the 17. Four patients had ulcerating endobronchial granuloma and all had biopsy samples positive for tuberculosis. Transbronchial or transcarinal needle aspiration samples were diagnostic in five of 11 patients (45%) subjected to the procedure. Peripheral lymph node biopsy diagnosed tuberculosis in two cases and in the remaining six patients the diagnosis wa achieved by mediastinoscopy or thoracotomy. CONCLUSIONS: Bronchoscopy has an important role in the diagnosis of intrathoracic tuberculous lymphadenopathy in adults and should be considered before other invasive procedures.


Assuntos
Doenças do Mediastino/diagnóstico , Tuberculose dos Linfonodos/diagnóstico , Adolescente , Adulto , Biópsia por Agulha , Broncoscopia , Feminino , Humanos , Masculino , Doenças do Mediastino/diagnóstico por imagem , Mediastinoscopia , Pessoa de Meia-Idade , Estudos Retrospectivos , Toracotomia , Tomografia Computadorizada por Raios X , Tuberculose dos Linfonodos/diagnóstico por imagem
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