Detalhe da pesquisa
1.
Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers.
Blood
; 141(12): 1411-1424, 2023 03 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36240433
2.
Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution.
Pharmacol Rev
; 72(2): 486-526, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32198236
3.
DRUGGING "UNDRUGGABLE" DISEASE-CAUSING PROTEINS: FOCUS ON SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT) 3.
Trans Am Clin Climatol Assoc
; 132: 61-76, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36196170
4.
Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility.
Pharmacol Res
; 169: 105637, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33932608
5.
Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease.
Am J Physiol Renal Physiol
; 319(1): F84-F92, 2020 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32475130
6.
Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40.
Am J Physiol Endocrinol Metab
; 318(5): E625-E635, 2020 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32101031
7.
Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors.
Org Biomol Chem
; 18(17): 3288-3296, 2020 05 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32286579
8.
Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome.
Blood
; 128(26): 3061-3072, 2016 12 29.
Artigo
Inglês
| MEDLINE | ID: mdl-27799162
9.
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment.
Int J Mol Sci
; 19(8)2018 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30081609
10.
Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.
J Biol Chem
; 291(9): 4732-41, 2016 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-26706127
11.
STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation.
FASEB J
; 30(1): 129-40, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26324850
12.
Modulation of STAT3 folding and function by TRiC/CCT chaperonin.
PLoS Biol
; 12(4): e1001844, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24756126
13.
Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.
J Allergy Clin Immunol
; 138(1): 187-199, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26948077
14.
Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.
Biophys J
; 110(11): 2377-2385, 2016 06 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27276256
15.
Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia.
J Biol Chem
; 290(17): 11177-87, 2015 Apr 24.
Artigo
Inglês
| MEDLINE | ID: mdl-25787076
16.
A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance.
J Cell Sci
; 126(Pt 11): 2446-58, 2013 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23572509
17.
FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report.
Blood
; 121(7): 1083-93, 2013 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-23243289
18.
STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer.
Stem Cells
; 32(10): 2571-82, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-24891218
19.
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.
Int J Mol Sci
; 16(11): 26706-20, 2015 Nov 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26561808
20.
Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity.
Angew Chem Int Ed Engl
; 54(44): 13085-9, 2015 Oct 26.
Artigo
Inglês
| MEDLINE | ID: mdl-26480340