Detalhe da pesquisa
1.
Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer's Disease.
Int J Mol Sci
; 22(21)2021 Nov 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34769380
2.
PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.
Prog Neurobiol
; 191: 101818, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32380223
3.
Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy.
Mol Ther Nucleic Acids
; 16: 26-37, 2019 Jun 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30825670
4.
Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.
ACS Chem Neurosci
; 10(3): 1765-1782, 2019 03 20.
Artigo
Inglês
| MEDLINE | ID: mdl-30525452
5.
Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles.
ACS Chem Neurosci
; 10(9): 4076-4101, 2019 09 18.
Artigo
Inglês
| MEDLINE | ID: mdl-31441641
6.
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Eur J Med Chem
; 150: 506-524, 2018 Apr 25.
Artigo
Inglês
| MEDLINE | ID: mdl-29549837
7.
Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.
ACS Chem Neurosci
; 8(3): 638-661, 2017 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27936591
8.
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.
J Med Chem
; 59(19): 8967-9004, 2016 10 13.
Artigo
Inglês
| MEDLINE | ID: mdl-27606546