RESUMO
PURPOSE: Since the relationship between mandibular setback surgery and obstructive sleep apnea (OSA) occurrence still remains controversial, the aim of this study was to assess the impact of bimaxillary orthognathic surgery on the probability of OSA development, using a home sleep test (HST) device. METHODS: The authors implemented a double-blinded prospective cohort study. All healthy patients with skeletal class III deformity were included in this study. Subjects were candidates for bimaxillary orthognathic surgery. OSA monitoring was performed by the pulmonologist, week 1 preoperatively (T0), 1 and 6 months postoperatively (T1, T2), with a specific brand of a HST device. The predictor variables were the amount of mandibular setback and maxillary advancement, separately. Changes in apnea-hypopnea index (AHI) and SpO2 1 and 6 months after surgery relative to T0 were the outcome variables. OSA severity was measured using AHI, and classified as mild (5
Assuntos
Cirurgia Ortognática , Procedimentos Cirúrgicos Ortognáticos , Apneia Obstrutiva do Sono , Adulto , Feminino , Humanos , Masculino , Maxila/cirurgia , Procedimentos Cirúrgicos Ortognáticos/efeitos adversos , Estudos Prospectivos , Apneia Obstrutiva do Sono/cirurgia , Adulto JovemRESUMO
OBJECTIVES: To investigate the frequency and possible role of Epstein-Barr virus infection in non-Hodgkin's lymphomas of the oral cavity and maxillofacial region in Khorasan (Northeast of Iran). METHODS: The cross-sectional retrospective study assessed the frequency of Epstein-Barr virus infection in non-immunosuppressed non-Hodgkin's lymphoma cases of the oral cavity and maxillofacial region. Formalin-fixed, paraffin-embedded tissue sections from 34 cases of head and neck non-Hodgkin's lymphoma (17 low-grade B-cell lymphoma, 14 diffuse large B-cell lymphoma, and 3 peripheral T cell lymphoma) were selected as a case group, and 10 normal lymph node sections were considered as a control group. Polymerase chain reaction was used to detect the EBV-DNA in tissue specimens. SPSS 16 was used for statistical analysis of the data. RESULTS: EBV-DNA was detected in 26.5% of NHL samples. Among NHLs, Epstein-Barr virus was found to be positive in 50% cases with diffuse large B-cell lymphoma and 11.8% of low grade B-cell lymphomas. Epstein-Barr virus was not detected in any cases of peripheral T-cell lymphoma. CONCLUSION: Although it seems that Epstein-Barr virus appears to be an etiological factor in some subtypes of non-Hodgkin's lymphomas, especially in diffuse large B-cell lymphoma, more researches should be done to investigate the relationship between Epstein-Barr virus infection and head and neck non-Hodgkin's lymphomas.
Assuntos
Infecções por Vírus Epstein-Barr/epidemiologia , Neoplasias de Cabeça e Pescoço/complicações , Linfoma não Hodgkin/complicações , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Estudos Transversais , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/virologia , Feminino , Seguimentos , Neoplasias de Cabeça e Pescoço/epidemiologia , Herpesvirus Humano 4/genética , Humanos , Hibridização In Situ , Irã (Geográfico)/epidemiologia , Linfoma não Hodgkin/diagnóstico , Linfoma não Hodgkin/epidemiologia , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Prevalência , RNA Viral/análise , Estudos Retrospectivos , Adulto JovemRESUMO
Background: We aimed to investigate the pharmacological and non-pharmacological interventions used for mitigating pain. Methods: We integrated randomized controlled trials (RCTs) chosen from PubMed, Google scholar, and Scopus and aimed at assessing the effectiveness of one or multiple variants of Non-steroidal anti-inflammatory drugs (NSAIDs), as well as Narcotic analgesics, compared to corticosteroids, curcumin, hyaluronic acid, and antibiotics. In addition, trials utilizing NSAIDs, including Rofecoxib, which have been withdrawn from market circulation, were deemed ineligible for inclusion. Result: A total of 9 RCTs were evaluated in this study, and the patients' postoperative pain was assessed using the visual analog scale (VAS) and the time measurement. Moreover, there were various approaches to alleviating pain and discomfort. Conclusion: The administration of ibuprofen prior to surgery leads to a marked reduction in pain. Pharmacological interventions, such as the administration of dexamethasone and oxycodone, alongside non-pharmacological interventions, such as laser therapy, have been shown to effectively alleviate the discomfort resulting from surgical procedures on the jaw and face.