Detalhe da pesquisa
1.
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Nature
; 510(7504): 283-7, 2014 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24847881
2.
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Nature
; 492(7427): 108-12, 2012 Dec 06.
Artigo
Inglês
| MEDLINE | ID: mdl-23051747
3.
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Bioorg Med Chem Lett
; 22(12): 4028-32, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22579486
4.
Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors.
Biochemistry
; 50(31): 6642-54, 2011 Aug 09.
Artigo
Inglês
| MEDLINE | ID: mdl-21711014
5.
Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor.
Biochem Biophys Res Commun
; 406(2): 194-9, 2011 Mar 11.
Artigo
Inglês
| MEDLINE | ID: mdl-21300025
6.
Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.
Anal Biochem
; 383(2): 311-5, 2008 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18814837
7.
Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.
Structure
; 24(5): 774-781, 2016 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27066749
8.
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.
Cancer Cell
; 28(1): 57-69, 2015 Jul 13.
Artigo
Inglês
| MEDLINE | ID: mdl-26175415
9.
First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling.
J Med Chem
; 46(1): 5-8, 2003 Jan 02.
Artigo
Inglês
| MEDLINE | ID: mdl-12502353
10.
Long residence time inhibition of EZH2 in activated polycomb repressive complex 2.
ACS Chem Biol
; 9(3): 622-9, 2014 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-24304166
11.
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Cancer Cell
; 23(5): 677-92, 2013 May 13.
Artigo
Inglês
| MEDLINE | ID: mdl-23680150
12.
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.
Epigenetics
; 7(4): 340-3, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22419068
13.
Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.
J Biomol Screen
; 17(10): 1279-92, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-22904200
14.
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
ACS Med Chem Lett
; 1(1): 39-43, 2010 Apr 08.
Artigo
Inglês
| MEDLINE | ID: mdl-24900173
15.
Phylogenomic and biochemical characterization of three Legionella pneumophila polypeptide deformylases.
J Bacteriol
; 188(14): 5249-57, 2006 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-16816197
16.
Mechanism of time-dependent inhibition of polypeptide deformylase by actinonin.
Biochemistry
; 44(1): 253-60, 2005 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-15628866