Detalhe da pesquisa
1.
Small molecules that target group II introns are potent antifungal agents.
Nat Chem Biol
; 14(12): 1073-1078, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30323219
2.
Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis.
Biochemistry
; 53(28): 4671-84, 2014 Jul 22.
Artigo
Inglês
| MEDLINE | ID: mdl-25007099
3.
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Bioorg Med Chem Lett
; 19(7): 2006-8, 2009 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19250825
4.
Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II.
J Med Chem
; 62(17): 8164-8177, 2019 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31408339
5.
Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.
Cell Chem Biol
; 25(10): 1231-1241.e4, 2018 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-30078634
6.
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
J Med Chem
; 48(9): 3141-52, 2005 May 05.
Artigo
Inglês
| MEDLINE | ID: mdl-15857120
7.
Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.
J Med Chem
; 56(6): 2568-80, 2013 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-23472952
8.
Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications.
Bioorg Med Chem
; 12(21): 5661-75, 2004 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15465344