Detalhe da pesquisa
1.
Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance.
Hum Mol Genet
; 32(7): 1072-1082, 2023 03 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36269083
2.
A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2.
Am J Hum Genet
; 109(7): 1208-1216, 2022 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35688148
3.
A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome.
Am J Hum Genet
; 109(7): 1199-1207, 2022 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35688147
4.
Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels.
Cell
; 141(6): 1018-29, 2010 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-20564790
5.
The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review.
Ann Noninvasive Electrocardiol
; 28(1): e13015, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36345173
6.
Arrhythmogenic effects of ultra-long and bistable cardiac action potentials.
PLoS Comput Biol
; 17(2): e1008683, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33591969
7.
Don't Turn Off the Tap! The Importance of Discovery Science to the Australian Cardiovascular Sector and Improving Clinical Outcomes Into the Future.
Heart Lung Circ
; 31(10): 1321-1332, 2022 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-35961820
8.
Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding.
Mol Pharmacol
; 95(5): 537-550, 2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30770456
9.
hERG K(+) channels: structure, function, and clinical significance.
Physiol Rev
; 92(3): 1393-478, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22988594
10.
Molecular Docking Guided Grid-Independent Descriptor Analysis to Probe the Impact of Water Molecules on Conformational Changes of hERG Inhibitors in Drug Trapping Phenomenon.
Int J Mol Sci
; 20(14)2019 Jul 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31295848
11.
The Temperature Dependence of Kinetics Associated with Drug Block of hERG Channels Is Compound-Specific and an Important Factor for Proarrhythmic Risk Prediction.
Mol Pharmacol
; 94(1): 760-769, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29728448
12.
Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy.
J Physiol
; 596(7): 1107-1119, 2018 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29377132
13.
Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.
J Physiol
; 596(10): 1813-1828, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29573276
14.
The S1 helix critically regulates the finely tuned gating of Kv11.1 channels.
J Biol Chem
; 292(18): 7688-7705, 2017 05 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28280240
15.
Potassium channels in the heart: structure, function and regulation.
J Physiol
; 595(7): 2209-2228, 2017 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27861921
16.
Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.
J Physiol
; 595(7): 2229-2252, 2017 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27808412
17.
Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation.
J Biol Chem
; 291(33): 17293-302, 2016 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27317659
18.
Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes.
J Mol Cell Cardiol
; 100: 25-34, 2016 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-27663173
19.
The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.
J Mol Cell Cardiol
; 97: 24-35, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27103460
20.
Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction.
Mol Pharmacol
; 90(1): 1-11, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27190211