Detalhe da pesquisa
1.
CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag.
Blood
; 138(6): 480-485, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34010413
2.
MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491.
Blood
; 135(12): 948-953, 2020 03 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31978223
3.
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Immunity
; 39(3): 443-53, 2013 Sep 19.
Artigo
Inglês
| MEDLINE | ID: mdl-24012422
4.
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity.
Immunity
; 36(2): 239-50, 2012 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-22342841
5.
An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.
Blood
; 128(26): 3146-3158, 2016 12 29.
Artigo
Inglês
| MEDLINE | ID: mdl-28034873
6.
Inhibition of IL-6 family cytokines by SOCS3.
Semin Immunol
; 26(1): 13-9, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24418198
7.
MPL membrane domain sequencing goes deep.
Blood
; 135(4): 236-237, 2020 01 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31972012
8.
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.
Biochem J
; 471(2): 255-65, 2015 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26283547
9.
The molecular regulation of Janus kinase (JAK) activation.
Biochem J
; 462(1): 1-13, 2014 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25057888
10.
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.
Biochem J
; 458(2): 395-405, 2014 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24354892
11.
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
Biochem J
; 457(2): 323-34, 2014 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24107129
12.
Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.
Growth Factors
; 32(1): 18-26, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24438083
13.
Clinical Impact of Comprehensive Molecular Profiling in Adolescents and Young Adults with Sarcoma.
J Pers Med
; 14(2)2024 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-38392562
14.
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Nat Commun
; 11(1): 3150, 2020 06 19.
Artigo
Inglês
| MEDLINE | ID: mdl-32561755
15.
The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: recent findings and potential therapeutic applications.
Expert Rev Hematol
; 12(6): 437-448, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31092065
16.
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer Cell
; 36(2): 123-138.e10, 2019 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31303423
17.
The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.
Front Endocrinol (Lausanne)
; 8: 59, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28408900
18.
MPL S505C enhances driver mutations at W515 in essential thrombocythemia.
Blood Cancer J
; 11(11): 188, 2021 11 29.
Artigo
Inglês
| MEDLINE | ID: mdl-34845187
19.
A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline.
Leukemia
; 35(11): 3295-3298, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33846542
20.
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer Cell
; 36(3): 340, 2019 Sep 16.
Artigo
Inglês
| MEDLINE | ID: mdl-31526763