Detalhe da pesquisa
1.
Biased 5-HT1A receptor agonists F13714 and NLX-101 differentially affect pattern separation and neuronal plasticity in rats after acute and chronic treatment.
Mol Cell Neurosci
; 120: 103719, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35283305
2.
The selective 5-HT 1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat.
Behav Pharmacol
; 33(5): 333-341, 2022 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35695543
3.
Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease.
Neurobiol Dis
; 152: 105278, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33516872
4.
Effects of the Serotonin 5-HT1A Receptor Biased Agonists, F13714 and F15599, on Striatal Neurotransmitter Levels Following L-DOPA Administration in Hemi-Parkinsonian Rats.
Neurochem Res
; 43(5): 1035-1046, 2018 May.
Artigo
Inglês
| MEDLINE | ID: mdl-29572645
5.
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
J Pharmacol Exp Ther
; 345(3): 502-11, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23520265
6.
NLX-101, a 5-HT1A receptor-biased agonist, improves pattern separation and stimulates neuroplasticity in aged rats.
Neurobiol Aging
; 124: 52-59, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36739621
7.
Dissecting the contribution of 5-HT1A auto- and heteroreceptors in sucrose overconsumption in mice.
Biomed Pharmacother
; 148: 112699, 2022 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-35152045
8.
Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: part II.
Bioorg Med Chem Lett
; 21(13): 3927-30, 2011 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21636273
9.
Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.
Bioorg Med Chem Lett
; 21(1): 520-3, 2011 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21095126
10.
Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators.
Bioorg Med Chem Lett
; 21(24): 7455-9, 2011 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22056742
11.
Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators.
Bioorg Med Chem Lett
; 21(20): 6170-5, 2011 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21889339
12.
Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.
Bioorg Med Chem Lett
; 21(5): 1438-41, 2011 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21310609
13.
Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.
Bioorg Med Chem Lett
; 21(5): 1434-7, 2011 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21310612
14.
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
Bioorg Med Chem
; 19(1): 663-76, 2011 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21093273
15.
The selective 5-HT1A receptor agonist, NLX-112, exerts anti-dyskinetic and anti-parkinsonian-like effects in MPTP-treated marmosets.
Neuropharmacology
; 167: 107997, 2020 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32057799
16.
Activation of 5-HT1A postsynaptic receptors by NLX-101 results in functional recovery and an increase in neuroplasticity in mice with brain ischemia.
Prog Neuropsychopharmacol Biol Psychiatry
; 99: 109832, 2020 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31809832
17.
In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry.
Biopharm Drug Dispos
; 30(1): 9-20, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19152227
18.
Serotonin 5-HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model.
ACS Chem Neurosci
; 10(7): 3101-3107, 2019 07 17.
Artigo
Inglês
| MEDLINE | ID: mdl-30929419
19.
Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model.
J Psychopharmacol
; 33(11): 1456-1466, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31290370
20.
Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT1A receptor sensitivity.
Neuropharmacology
; 153: 134-141, 2019 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31078489