Skin cancer prevention campaign in childhood: survey based on 3676 children in Brazil.

BACKGROUND AND OBJECTIVES: Primary skin cancer prevention campaigns are essential and more effective among children, not only because of the importance of sun exposure effects during this period, but also because this age is when individuals are developing behaviours. The Brazilian Society of Dermatology - Regional State of Sao Paulo developed and conducted the programme named 'The Sun, Friend of Childhood', a school health education and disease prevention project for children and parents. Our objective was to evaluate the cognitive and behavioural effects of the children and parents before and after an education model-based intervention of sun protection. METHODS: We carried out a study on a school population of Social Service of Industry - Regional State of São Paulo, from the first to the fifth years of the regular course (6-10 years). Our educational project was planned to be based on two children's learning tools (comic magazine and a DVD cartoon). Questionnaires in relation to habits and knowledge in sun exposure were applied to the children (3776) before and (2748) after the intervention. A questionnaire was applied to 3663 parents regarding personal details and habits of their children. RESULTS: According to the McNemar's statistical test, all changes in the children in acquiring new knowledge about good practices for sun exposure were statistically significant. CONCLUSIONS: Educative sun exposure programmes in childhood are a relevant tool to modify the history of life for next generations, to concern the skin cancer and good health practices.

Atopy patch test with Aleuroglyphus ovatus antigen in patients with atopic dermatitis.

BACKGROUND: Epicutaneous test made with dust mite antigens. OBJECTIVE: Evaluation of the response of the epicutaneous test with Aleuroglyphus ovatus antigen in atopic patients. METHODS: We patch tested 119 individuals, 48 with atopic dermatitis, 50 with respiratory allergy and 21 healthy controls. We compare the positive response frequency to a closed patch test using Aleuroglyphus ovatus antigen in different concentrations and 48 and 96h reading times among those individuals. RESULTS: Six patients with atopic dermatitis (12.5%) and 4 with respiratory atopy (8.0%) had positive reactions. None of the non-atopic controls had a positive response. As the antigen concentration raised, the number of positive reactions to epicutaneous test raised as well. CONCLUSION: Our data suggest a positive relation between Atopy Patch Test positive responses and Aleuroglyphus ovatus antigen concentration, no matter the kind of the atopic clinical expression.

Itraconazole vs. trimethoprim-sulfamethoxazole: A comparative cohort study of 200 patients with paracoccidioidomycosis.

Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America. Brazil accounts for approximately 80% of cases, where it represents a major public health issue due to its disabling impact and the number of premature deaths it causes. We present a retrospective cohort study that was conducted in order to better understand factors that relate to cure of the infection in the treatment of 200 patients with PCM. We evaluated the influence of sociodemographic and clinical factors as well as therapeutic regimen (trimethoprim-sulfamethoxazole [TMP-SMX] and itraconazole) on the progress of PCM (cure and noncure). There was a higher incidence of cure (83%) among patients who regularly received treatment for their infections and completed the treatment protocol. Moreover, itraconazole (86.4%) was significantly superior to TMP-SMX (51.3%) in terms of cure rate and had a median treatment period that was significantly shorter (12 months) than that for TMP-SMX (23 months). A Cox proportional hazard regression model showed that use of itraconazole increased the hazard of cure, regardless of sex, age, education, clinical form, completion of treatment, and regularity. Although the results of this study show that itraconazole was the best treatment option for PCM patients, a double-blind, randomized, controlled trial is necessary to confirm this conclusion.

Dermal dendrocytes FXIIIA+ phagocytizing extruded mast cell granules in drug-induced acute urticaria.

BACKGROUND: Few authors have been attempting between mast cells and dermal dendrocytes interactions on urticaria. OBJECTIVE: To describe the extruded mast cell granules and dermal dendrocytes in drug-induced acute urticaria. METHODS: Seven patients with drug-induced acute urticaria were enrolled in the study. We token skin biopsies of urticaria lesion and perilesional skin. The 14 fragments collected were processed to immunogold electron microscopy using single stains to tryptase and FXIIIa, besides double immunogold labeling with both. RESULTS: Some sections demonstrated mast cells in degranulation process, both in anaphylactic and piecemeal degranulation types. After double immunogold staining, 10 nm (FXIIIa) and 15 nm (Tryptase) gold particles were present together over the granules in mast cells indicating that tryptase and FXIIIa are each localized within the granules of these cells. Interestingly, we found a strong evidence of than the exocytosed mast cell granules contents both FXIIIa and tryptase immunolabeled are phagocytized by dermal dendrocytes. CONCLUSIONS: The current observations provide morphological evidence that the exocytosis-phagocytosis mechanisms of mast cell granules represents one pathophysiological example of mast cells-dermal dendrocytes interactions in urticaria.

Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin.

Obstruction of airways by viscous sputum causes lung damage in patients with cystic fibrosis (CF). Sputum samples from CF patients were shown to contain filamentous actin. Human plasma gelsolin, a protein that severs actin filaments, rapidly decreased the viscosity of CF sputum samples in vitro. Gc globulin and deoxyribonuclease I, proteins that sequester monomeric actin but do not sever actin filaments, were less efficient than gelsolin in diminishing sputum viscosity. These results suggest that gelsolin may have therapeutic potential as a mucolytic agent in CF patients.

Allergic contact dermatitis to temporary tattoo by p-phenylenediamine.

Temporary tattoos are widely applied today all over the world. The tattoo makers explain that they use "natural henna paint," although in fact they use "black henna," which includes a mixture of many substances, among them p-phenylenediamine (PPD). There have recently been many reports of allergic contact dermatitis because of temporary tattoo with PPD sensitization. We are adding a new case of temporary tattoo with black henna with an extensive reaction, in which a 12-year-old white boy showed contact dermatitis from PPD, followed by cutaneous eruption after corticosteroid topical treatment.

Necrobiotic xanthogranuloma with lambda paraproteinemia: case report of successful treatment with melphalan and prednisone.

BACKGROUND: Necrobiotic xanthogranuloma (NXG) is a rare non-X histiocytosis with conspicuous lesions on the periorbital skin. METHODS: A diabetic patient presented with NXG and a previous diagnosis of necrobiosis lipoidica on the legs over a period of almost 2 years before the development of the typical lesions of NXG on the periorbital regions, back, thighs and legs. The patient was found also to have developed lambda paraproteinemia. RESULTS: Treatment with melphalan and prednisone resulted in great improvement of cutaneous lesions and paraproteinemia remission. CONCLUSION: This case report details how melphalan and prednisone can be administered in the successful treatment of necrobiotic xanthogranuloma with lambda paraproteinemia.

Erythroderma: analysis of 247 cases.

The profile of 247 patients with erythroderma during a 23 year period from January, 1962 through March, 1985, with a follow-up period ranging from 1 to 26 years were analysed. The patients presented with diffuse erythema, scaling and pruritus of more than 2 months' duration, and the age ranged from 16 to 60 years. Psoriasis was the most frequent underlying disease with an estimated frequency of 44.9%, the reaction to the use of drugs appeared in 7.3% of total cases and association with reticulosis showed a frequency of 4.1%. The cause of the erythroderma could not be determined in 29.2% of the cases. Six differences in terms of underlying diseases were not observed. One or more skin biopsies along with clinical findings were diagnostic or suggestive of the underlying disease in 63.6% of the cases. Repeated skin biopsies are recommended as the best method for etiologic diagnosis of erythroderma. At P = 0.05 significance level, masculine/feminine ratio of 2:1 was found. The question arises whether causal agent of erythroderma may not be somehow related to different exposure by sex to environmental antigens.

[Risk factors for chronic non-communicable diseases: a domiciliary survey in the municipality of São Paulo, SP (Brazil). Methodology and preliminary results]. / Factores de risco para doenças crônicas não-transmissíveis: inquérito domiciliar no município de São Paulo, SP (Brasil). Metodologia e resultados preliminares.

The non-communicable chronic diseases are important causes of death in Brazil, mainly in the great urban centres. There are various risk factors related to these diseases, whose remotion or attenuation would contribute to a fall in mortality. The methodology of the first comprehensive multicenter study into risk factors of non-communicable chronic diseases carried out in Latin America is explained. In Brazil, this study was carried out in the cities of S. Paulo, SP and Porto Alegre, RS. Preliminary results from the city of S. Paulo as to the prevalence of arterial hypertension (22.3%), tabagism (37.9%), obesity (18.0%), alcoholism (7.7%) and sedentarism (69.3%) are presented. These results are compared with existing data from Brazil and other countries, and the relationship between various risk factors and the mortality from cardiovascular diseases in S. Paulo and some developed countries is discussed.

Trichophyton raubitschekii: a new agent of dermatophytosis in Brazil?

A microbiological and ultrastructural study of Trichophyton raubitschekii recovered from a patient with tinea faciei is presented. This is the second case of isolation of this fungus in Sao Paulo and the sixth case in Brazil. Upon culture, the morphological pattern and the physiological tests performed confirmed the identification of T. raubitschekii. The ultrastructural study of T. raubitschekii showed the presence of a membrane-like structure located in the outer portion of the hyphal walls. This structure was bi-stratified and very like the one observed in T. rubrum. Is T. raubitschekii a new fungus emerging in Brazil or is it a T. rubrum variant?

Persistence of Leishmania antigen in C57Bl/6j inbred mice infected with Leishmania (Leishmania) amazonensis.

PURPOSE: To develop an animal model for studying mucocutaneous leishmaniasis. METHODS: The hind footpad of C57Bl/6j inbred mice was experimentally infected with 10(7) Leishmania (Leishmania) amazonensis promastigote and the skin was studied through light and electron transmission microscopy and immunohistochemistry (PAP) techniques. RESULTS: There were morphological evidences of cellular immune mechanisms and hypersensitivity reaction after eight weeks of infection and metastasis and well shaped parasites at ultrastructural level by fifty-one weeks post infection. Relapse of infection with mucosa lesions occurred around the 50th week after inoculation. CONCLUSION: The use of this animal model in long term follow up could be an useful experimental model for human mucocutaneous leishmaniasis.

[Primary cutaneous malignant melanoma: retrospective studyfrom 1963 to 1997 at Hospital do Servidor Público Estadual de São Paulo]. / Melanoma maligno cutâneo primário: estudo retrospectivo de 1963 a 1997 no Hospital do Servidor Público Estadual de São Paulo.

OBJECTIVES: A retrospective study on the Primary Cutaneous Malignant Melanoma in the Hospital do Servidor Público Estadual de São Paulo (HSPE-SP) analyzing its distribution according to age, sex, race and cutaneous site. METHODOLOGY: We studied 222 patients with Primary Cutaneous Malignant Melanoma as diagnosed at Hospital do Servidor Público Estadual de São Paulo, Brazil between the period from 1963 to 1997. A retrospective study was performed. Data were expressed as inance of caucasians (98.19%) over afro-americans (1.81) and of the female sex (69.36%) over the male sex (30.63%) was found. The predominant age on the occasion of the diagnosis was between 50 and 60 years for the women (25.32%) and between 60 and 69 years for the men (22.52%). The most frequent site of the cancer in men was the back region (29.41%) and in the lower members in the women (38.31%). The most frequent level of the tumor invasion (Clark) was IV (39.77%), and the average of tumor thickeness (Breslow) was < 0.75 mm (28.4%). A 5 years survival was observed in 73.3% of the patients. CONCLUSIONS: At our Hospital the incidence of Primary Cutaneous Malignant Melanoma has shown an increase in recent years; these results are compatible with the most recent international surveys.

[Acquired epidermolysis bullosa (acquired dermolytic bullous dermatoses) (study of 2 patients)]. / Epidermólise bolhosa adquirida (dermatose bolhosa dermolítica adquirida) (estudo de 2 doentes).

The authors studied two patients with bullous lesions with onset at adult age. There were no relatives with bullous disease. After minor traumas, mainly in hands, feet, elbows and knees, one could see the onset of the blisters, which vanished leaving atrophic scars. Nails and mucosae were involved in both patients. The female patient had cyst of milia. One of the patients had lymph node tuberculosis as associated disease. Through exhaustive clinical examination and laboratory investigation, the authors excluded other types of bullous diseases. Histopathology of the lesions, electron microscopy, direct and indirect immunofluorescence, supported the diagnosis of Acquired Dermolytic Bullous Dermatosis.

Evaluación de la actividad anti-inflamatoria de propóleos chileno sobre cortes histológicos de orejas de ratón / Evaluation of the anti-inflammatory activity of Chilean propolis on histological sections of mouse ears

RESUMEN: El propóleos es un producto resinoso complejo producido por las abejas Apis mellifera, el cual posee diversas actividades biológicas como inmunomodulador, antiinflamatorio, anticancerígeno, antiviral, antibacteriano, antioxidante, entre otros. El propósito del siguiente estudio fue realizar una evaluación in vivo de las propiedades antiinflamatorias de un extracto de propóleos chileno, sobre el modelo de edema auricular inducido por 13-acetato-12-O-tetradecanoilforbol (TPA) en pabellón auricular de ratón, para posterior evaluación y análisis histológico. El extracto de propóleos chileno (EEP) utilizado se obtuvo a partir de un macerado etanólico, rotaevaporado y liofilizado. Se observó que el EEP disminuyó el edema y el infiltrado inflamatorio de forma significativa. Estos resultados sugieren que el extracto etanólico de propóleos chileno posee potenciales efectos antiinflamatorios o moduladores del sistema inmunológico en edema auricular.

SUMMARY: Propolis is a complex resinous product produced by bees Apis mellifera, which has a number of biological activities such as an immunomodulator, anti-inflammatory, anticarcinogenic, antiviral, antibacterial, antioxidant, among others. The purpose of the following study was to perform an in vivo evaluation of the anti-inflammatory properties of a Chilean propolis extract, on the model of atrial edema induced 12-O-tetradecanoyl phorbol-13- acetate (TPA) in the mouse auricular pavilion, for later evaluation and histological analysis. The Chilean propolis extract (EPP) used was obtained from an ethanolic, rotaevaporated and lyophilized macerate. It was observed that the EPP significantly decreased edema and inflammatory infiltrate. These results suggest that the ethanolic extract of Chilean propolis possesses potential anti-inflammatory or modulatory effects of the immune system in atrial edema.

1, 25-dihidroxivitamina-D 3 sobre as características ósseas de frangos de corte fêmeas / 1, 25-dihydroxyvitamin-D3 over bony characteristics of female broilers

Objetivou-se avaliar as características dos tibiotarsos de frangos de corte fêmeas. As variáveis analisadas foram os pesos in natura, secos e desengordurados, o comprimento, os diâmetros, a resistência óssea, o índice de Seedor (IS), os percentuais de proteínas colagenosas (PC), as proteínas não colagenosas (PNC), os minerais (cálcio, fósforo, potássio e sódio) e as cinzas. Foram utilizadas 648 aves, da marca comercial Cobb®, em um delineamento em blocos ao acaso, com seis tratamentos e seis repetições, com 18 aves por unidade experimental. Os tratamentos consistiram na suplementação de 0,00; 0,50; 1,00; 1,50; 2,00 e 2,50 µg de 1,25-dihidroxivitamina-D3 (1,25(OH)2D3)/kg de ração. Aos 21 e 35 dias de idade, as aves foram pesadas e uma ave por unidade experimental (UE) com o peso médio da UE foi eutanasiada para a obtenção dos tibiotarsos e subsequente análise dos parâmetros ósseos. As variáveis métricas, bem como a composição orgânica (PC), a densidade (IS) e a resistência à quebra dos ossos das aves, não foram influenciadas pelos tratamentos. No recebimento de 2,50 µg de 1,25(OH)2D3/kg de ração, observou-se maior retenção mineral (cinzas) nos ossos das aves aos 35 dias de idade.(AU)

This study aimed to evaluate the characteristics of tibiotarsus of female broilers. The variables analyzed were the weights in natura, dry and degreased, length, diameter, bone strength, Seedor index, percentage of collagenous protein (CP), non-collagenous proteins (NCP), minerals (calcium, phosphorus, potassium and sodium), and ash. Six hundred forty-eight, Cobb® birds were used, a design of randomized blocks with six treatments and six replicates of 18 birds each. The treatments consisted of supplementation of 0.00; 0.50; 1.00; 1.50; 2.00 to 2.50 µg of 1,25-dihydroxyvitamin-D3 (1,25(OH)2D3)/kg of ration. At 21 and 35 days of age the birds were weighed and a unit/experimental unit (EU) with the EU average weight was euthanized to obtain the tibiotarsos and subsequent analysis of the bone parameters. The metric variables, as well as the organic composition (CP), density (IS) and resistance to breakage of the bones of the birds were not affected by treatments. Upon reception of 2.50 µg of 1,25(OH)2D3/kg ration, there was a higher mineral retention (ashes) in the bones of female broilers at 35 days of age.(AU)

Factors associated with epidemic multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions.

INTRODUCTION: Infections caused by multiresistant Pseudomonas aeruginosa (MR-PA) have been associated with persistent infections and high mortality in acquired immunodeficiency syndrome (AIDS) patients. Therefore, understanding the predisposing factors for infection/colonization by this agent is critical for controlling outbreaks caused by MR-PA in settings with AIDS patients. OBJECTIVE AND METHODS: To analyze the presence of factors associated with the acquisition of an epidemic MR-PA strain in a hospital with AIDS-predominant admission. A case-control study was carried out in which cases and controls were gathered from a prospective cohort of all hospitalized patients in an infectious disease hospital during a five-year study period. RESULTS: Multivariate logistic regression analysis demonstrated that enteral nutrition OR = 14.9), parenteral nutrition (OR = 10.7), and use of ciprofloxacin (OR = 8.9) were associated with a significant and independent risk for MR-PA acquisition. CONCLUSIONS: Although cross-colonization was likely responsible for the outbreaks, the use of ciprofloxacin was also an important factor associated with the acquisition of an epidemic MR-PA strain. More studies are necessary to determine whether different types of nutrition could lead to modification of gastrointestinal flora, thereby increasing the risk for infection/colonization by MR-PA in this population.

Distribución de receptores de estrógenos beta en el ovario de ovejas prepúberes / Beta estrogen receptors distribution in the ovary of ewe lambs

Las hormonas esteroidales tienen un papel esencial en la fisiología reproductiva, actúan en el ovario estableciendo comunicación entre este y la glándula hipofisiaria y también en forma paracrina como reguladores locales. Se ha descrito expresión de receptores de estrógeno a nivel de ovarios fetales, neonatales y adulto, siendo necesario determinar cuales son los tipos celulares que expresan estos receptores. El ovario ovino es estereogénico activo desde la etapa fetal y por lo tanto los esteroides desempeñan un importante papel en el desarrollo gonadal. La regulación del crecimiento folicular está relacionado a varios factores por un lado la secreción de gonadotropinas por la hipófisis interviene durante el desarrollo folicular tardío, existiendo evidencias de una acción intra-ovárica directa de los estrógenos, en la regulación del crecimiento folicular temprano. Nuestro objetivo fue, evaluar la expresión y distribución de receptores de estrógeno b en las distintas poblaciones celulares del ovario de la oveja prepúber.

Steroid hormones play an essential role in reproductive physiology, acting in the ovary establishing communication between it and the pituitary gland as well as local paracrine regulators. Described estrogen receptor expression level fetal, neonatal and adult ovaries, which are necessary to determine the cell types that express these receptors. Sheep ovarian stereogenic is active from the fetal stage and therefore steroids play an important role in gonadal development. The regulation of follicle growth is related to several factors on the one hand the secretion of gonadotropins by the pituitary follicular development occurring during late, there was evidence of a direct intra-ovarian estrogen action in the early follicular growth regulation. Our objective was to evaluate the expression and distribution of estrogen receptor b in different cell populations of the ovary of prepubertal sheep.

Antinociceptive and anti-inflammatory activities of Bowdichia virgilioides (sucupira).

ETHNOPHARMACOLOGICAL RELEVANCE: Bowdichia virgilioides Kunth (Leguminosae Papilonoideae) is a plant with anti-inflammatory activity used in folk medicine. The importance of this plant promoted its inclusion in Brazilian Pharmacopoeia. AIM OF THE STUDY: In order to evaluate the actions of this plant, studies were performed on antinociceptive and anti-inflammatory activities. MATERIALS AND METHODS: The aqueous extracts (AE) of Bowdichia virgilioides inner bark and leaves were used at 100, 200, and 400mg/kg. Antinociceptive activity of plant extract was evaluated by writhing, hot-plate and formalin tests. Anti-inflammatory activity was evaluated using paw oedema and peritonitis methods. RESULTS: Oral treatment with the AE of inner bark or leaves elicited inhibitory activity (P<0.01) on acetic acid effect at 200 and 400mg/kg, and reduced the formalin effect at the second-phase (200 and 400mg/kg, P<0.01), however it did not elicit any inhibitory effect on hot-plate test. The indomethacin inhibited the acetic acid-induced writhing and the formalin effect at the second-phase (P<0.001), and the morphine reduced the both phases of formalin test (P<0.001). Carrageenan-induced oedema formation and neutrophil migration into the peritoneal cavity were reduced with the AE of inner bark or leaves at 100, 200, and 400mg/kg (P<0.05), and by the reference compounds aspirin (P<0.001) and dexamethasone (P<0.001), respectively. CONCLUSIONS: The AE of Bowdichia virgilioides shows antinociceptive and anti-inflammatory activities, supporting the folkloric usage of the plant to treat various inflammatory diseases.

Avaliação de níveis de glicina+serina em dietas de frangos de corte com reduzido teor de proteína bruta / Evaluation of glycine+serine levels in low crude protein diets for broiler chickens

O experimento foi conduzido em delineamento inteiramente ao acaso para avaliar os efeitos de diferentes níveis de glicina+serina (gli+ser) total em dietas de baixa proteína bruta (PB) sobre o desempenho e características de carcaça de frangos de corte de um a 21 dias de idade. Foram utilizadas 750 aves, distribuídas em cinco tratamentos, cinco repetições e 30 aves por unidade experimental. As dietas utilizadas continham 190g/kg de PB e níveis de gli+ser de 16,7; 19,2; 21,7 e 24,2g/kg; a dieta controle continha 230g/kg de PB. Avaliaram-se os efeitos dos níveis de glicina+serina sobre o desempenho e composição de carcaça. Os dados foram submetidos à análise de variância e os resultados obtidos com as dietas de baixos níveis proteicos com diferentes níveis de gli+ser foram comparados à dieta controle pelo teste de Dunnett. Os níveis de gli+ser apresentaram efeito linear sobre a conversão alimentar, ganho de peso e peso aos 21 dias, sendo o nível de 24,2g/kg de gli+ser com resultado semelhante à dieta controle. A redução proteica aumentou o conteúdo de extrato etéreo na carcaça.(AU)

A completely randomized experimental design was carried out to evaluate the effects of total gly+ser levels in low crude protein diets on performance and body composition of male broiler chickens from 1 to 21 days of age. Seven hundred and fifty broiler chickens were used in each one of the production phases. The birds were randomly allotted to five treatments and five replicates. The diets contained 190g/kg crude protein (CP) and total gly+ser levels of 16.7; 19.2; 21.7 and 24.2g/kg; and a control diet with 230 g/kg CP. The effect of glycine+serine levels on performance and body composition was evaluated. Data were subjected to analysis of variance and the results obtained with the diets of low crude protein levels with different levels of Gly + Ser were compared to the control diet by Dunnett's test. The gly+ser levels improved the feed linearly: weight gain ratio; weight gain and final weight. The broilers fed 24.2g/kg gly+ser diet showed a performance similar to broilers fed control diets. The carcass fat increased with CP reduction.(AU)

Suplemento de 1, 25 dihidroxicolecalciferol e redução de cálcio e fósforo disponível para frangos de corte / Supplement of 1, 25-dihydroxycholecalciferol and reduction of calcium and available phosphorus in broiler chickens

Avaliaram-se o desempenho e o rendimento de carcaça e cortes nobres de frangos de corte machos com suplemento nas rações de 1,25 dihidroxicolecalciferol e redução de cálcio e fósforo disponível. Foi utilizado um delineamento em blocos ao acaso, com seis tratamentos: 0,0; 1,0; 2,0; 3,0; 4,0 e 5,0µg de vitamina D3 ativa/kg de ração, e seis repetições com 17 aves cada. Aos 8 e 42 dias de idade cada unidade experimental foi pesada para avaliação do desempenho. Posteriormente, quatro aves/repetição foram retiradas e abatidas para mensuração do rendimento de carcaça e de cortes nobres. A inclusão da vitamina D3 ativa influenciou positivamente (P<0,05) o ganho de peso e a conversão alimentar com as suplementações de 1,0 e 2,0µg/kg. O consumo de ração não apresentou diferença significativa para os níveis estudados. O rendimento de carcaça e de cortes nobres de frangos de corte machos aos 42 dias não foram influenciados pelo suplemento de 1,25 dihidroxicolecalciferol e redução de cálcio e fósforo disponível nas rações. Recomenda-se o fornecimento suplementar de 1,0 a 2,0µg/kg de vitamina D3 ativa nas rações para frangos de corte machos de 8 a 42 dias de idade.

There were evaluated the performance, the carcass yield and noble cuts yield of broilers with supplement of 1,25-dihydroxycholecalciferol and reduction of calcium and available phosphorus. It was used a randomized block design, with six treatments: 0.0; 1.0; 2.0; 3.0; 4.0 and 5.0µg of active vitamin D3/kg of ration, and six repetitions with 17 birds each. At 8 and 42 days of age each experimental unit was weighted in order to evaluated the performance. Later, four broilers/repetition were removed and slaughtered in order to measure the carcass and noble cuts yield. The inclusion of active vitamin D3 influenced positively (P<0.05) the weight gain and the feed conversion at the supplementations of 1.0 and 2.0µg/kg. The feed intake wasn't significative among the studied levels. The carcass and noble cuts of male broilers at 42 days were not influenced by supplement of 1,25-dihydroxycholecalciferol and reduction of calcium and available phosphorus in rations. It is recommended to provide additional of 1.0 up to 2.0µg/kg of active vitamin D3 in rations for male broilers from 8 to 42 days of age.