Detalhe da pesquisa
1.
Morita-Baylis-Hillman adducts derived from thymol: synthesis, in silico studies and biological activity against Giardia lamblia.
Mol Divers
; 26(4): 1969-1982, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-34482477
2.
Synthesis, anti-proliferative activity, theoretical and 1H NMR experimental studies of Morita-Baylis-Hillman adducts from isatin derivatives.
Mol Divers
; 24(1): 265-281, 2020 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-30955150
3.
The Role Ionic Liquid [BMIM][PF6] in One-Pot Synthesis of Tetrahydropyran Rings through Tandem Barbier-Prins Reaction.
Molecules
; 24(11)2019 May 31.
Artigo
Inglês
| MEDLINE | ID: mdl-31159274
4.
One-Electron Reduction Potentials: Calibration of Theoretical Protocols for Moritaâ»Baylisâ»Hillman Nitroaromatic Compounds in Aprotic Media.
Molecules
; 23(9)2018 Aug 24.
Artigo
Inglês
| MEDLINE | ID: mdl-30149493
5.
Morita-Baylis-Hillman Adducts Display Anti-Inflammatory Effects by Modulating Inflammatory Mediator Expression in RAW264.7 Cells.
Mediators Inflamm
; 2017: 6898505, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28785138
6.
Antihyperalgesic effect of [(±)-(2,4,6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl]methanol: participation of the NO/cGMP/KATP pathway and κ-opioid receptor.
Behav Pharmacol
; 27(6): 506-15, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27035064
7.
Synthesis and activity of novel homodimers of Morita-Baylis-Hillman adducts against Leishmania donovani: A twin drug approach.
Bioorg Med Chem Lett
; 26(18): 4523-4526, 2016 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27520941
8.
The antinociceptive properties of the novel compound (±)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one in acute pain in mice.
Behav Pharmacol
; 24(1): 10-9, 2013 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-23263483
9.
High analgesic and anti-inflammatory in vivo activities of six new hybrids NSAIAs tetrahydropyran derivatives.
Bioorg Med Chem
; 21(19): 6003-10, 2013 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23953687
10.
Morita-Baylis-Hillman adducts: biological activities and potentialities to the discovery of new cheaper drugs.
Bioorg Med Chem
; 20(13): 3954-71, 2012 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22632793
11.
Antinociceptive activity of (-)-(2S,6S)-(6-ethyl-tetrahydropyran-2-yl)-formic acid on acute pain in mice.
Behav Pharmacol
; 22(5-6): 564-72, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21562408
12.
Design, synthesis and antileishmanial in vitro activity of new series of chalcones-like compounds: a molecular hybridization approach.
Bioorg Med Chem
; 19(14): 4250-6, 2011 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21684751
13.
3-Hydroxy-2-methylene-3-(4-nitrophenylpropanenitrile): A new highly active compound against epimastigote and trypomastigote form of Trypanosoma cruzi.
Bioorg Chem
; 38(5): 190-5, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20638707
14.
Efficient synthesis of 16 aromatic Morita-Baylis-Hillman adducts: Biological evaluation on Leishmania amazonensis and Leishmania chagasi.
Bioorg Chem
; 38(6): 279-84, 2010 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-20855101
15.
Synthesis, Cytotoxic Activity on Leukemia Cell Lines and Quantitative Structure-Activity Relationships (QSAR) Studies of Morita-Baylis-Hillman Adducts.
Med Chem
; 12(7): 602-612, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27150963
16.
Trypanosoma cruzi cell death induced by the Morita-Baylis-Hillman adduct 3-Hydroxy-2-methylene-3-(4-nitrophenylpropanenitrile).
PLoS One
; 9(4): e93936, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24714638
17.
Design, Prins-cyclization reaction promoting diastereoselective synthesis of 10 new tetrahydropyran derivatives and in vivo antinociceptive evaluations.
Eur J Med Chem
; 58: 1-11, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23085140
18.
Antimitotic activity on sea urchin embryonic cells of seven antiparasitic Morita-Baylis-Hillman adducts: a potential new class of anticancer drugs.
Med Chem
; 8(6): 1003-11, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-22830498
19.
Synthesis, evaluation against Leishmania amazonensis and cytotoxicity assays in macrophages of sixteen new congeners Morita-Baylis-Hillman adducts.
Eur J Med Chem
; 46(9): 4295-301, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21775030
20.
Improved synthesis of seven aromatic Baylis-Hillman adducts (BHA): evaluation against Artemia salina Leach. and Leishmania chagasi.
Eur J Med Chem
; 44(4): 1726-30, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18448204