1.
J Am Chem Soc
; 142(23): 10477-10484, 2020 06 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32379433
RESUMO
The palladium-catalyzed, α-selective hydroarylation of acrylates and acrylamides is reported. Under optimized conditions, this method is highly tolerant of a wide range of substrates including those with base sensitive functional groups and/or multiple enolizable carbonyl groups. A detailed mechanistic study was undertaken, and the high selectivity of this transformation was shown to be enabled by the formation of a [PdII(Ar)(H)] intermediate, which performs selective hydride insertion into the ß-position of α,ß-unsaturated carbonyl compounds.