Detalhe da pesquisa
1.
RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation.
Int J Mol Sci
; 25(5)2024 Mar 06.
Artigo
Inglês
| MEDLINE | ID: mdl-38474284
2.
Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD).
Int J Mol Sci
; 24(6)2023 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36982372
3.
BIO101 stimulates myoblast differentiation and improves muscle function in adult and old mice.
J Cachexia Sarcopenia Muscle
; 15(1): 55-66, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38064183
4.
Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial.
EClinicalMedicine
; 68: 102383, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38545090
5.
A Phase 1 study for safety and pharmacokinetics of BIO101 (20-hydroxyecdysone) in healthy young and older adults.
J Cachexia Sarcopenia Muscle
; 14(3): 1259-1273, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37057316
6.
20-Hydroxyecdysone, from Plant Extracts to Clinical Use: Therapeutic Potential for the Treatment of Neuromuscular, Cardio-Metabolic and Respiratory Diseases.
Biomedicines
; 9(5)2021 Apr 29.
Artigo
Inglês
| MEDLINE | ID: mdl-33947076
7.
Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients.
Drug Discov Today
; 26(5): 1311-1318, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33609783
8.
A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality.
Emerg Microbes Infect
; 10(1): 2256-2263, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-34783636
9.
20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor.
J Mol Endocrinol
; 68(2): 77-87, 2021 12 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34825653
10.
A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -ß/δ, -γ, and RXR antagonists and by norbixin.
Aging (Albany NY)
; 13(18): 22040-22058, 2021 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-34544906
11.
Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors.
Oxid Med Cell Longev
; 2020: 4984927, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33520083
12.
Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.
Aging (Albany NY)
; 12(7): 6151-6171, 2020 04 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32255762
13.
Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo.
PLoS One
; 11(12): e0167793, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27992460
14.
Quinoa extract enriched in 20-hydroxyecdysone affects energy homeostasis and intestinal fat absorption in mice fed a high-fat diet.
Physiol Behav
; 128: 226-31, 2014 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24534167
15.
Quinoa extract enriched in 20-hydroxyecdysone protects mice from diet-induced obesity and modulates adipokines expression.
Obesity (Silver Spring)
; 20(2): 270-7, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-21869758
16.
Toward positional cloning of Vgt1, a QTL controlling the transition from the vegetative to the reproductive phase in maize.
Plant Mol Biol
; 48(5-6): 601-13, 2002.
Artigo
Inglês
| MEDLINE | ID: mdl-11999837