Detalhe da pesquisa
1.
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
Bioorg Med Chem Lett
; 27(21): 4858-4866, 2017 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28958625
2.
N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.
Bioorg Med Chem Lett
; 26(8): 1894-900, 2016 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26988308
3.
Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
Bioorg Med Chem Lett
; 24(15): 3307-14, 2014 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24969015
4.
N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.
Bioorg Med Chem Lett
; 23(13): 3713-8, 2013 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23727046
5.
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.
Bioorg Med Chem Lett
; 23(18): 5091-6, 2013 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23932792
6.
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Bioorg Med Chem Lett
; 23(1): 346-50, 2013 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23177787
7.
Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
Bioorg Med Chem Lett
; 23(21): 5779-85, 2013 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24074843
8.
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
Drug Metab Dispos
; 40(9): 1834-45, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22711749
9.
Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.
Bioorg Med Chem Lett
; 21(9): 2711-4, 2011 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21183344
10.
Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation.
J Med Chem
; 60(12): 5072-5085, 2017 06 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28530802
11.
Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.
J Med Chem
; 58(22): 9027-40, 2015 Nov 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26524606
12.
Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.
J Med Chem
; 58(18): 7485-500, 2015 Sep 24.
Artigo
Inglês
| MEDLINE | ID: mdl-26335039
13.
Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system.
J Interferon Cytokine Res
; 23(5): 247-57, 2003 May.
Artigo
Inglês
| MEDLINE | ID: mdl-12804067
14.
A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors.
ACS Chem Neurosci
; 5(7): 597-610, 2014 Jul 16.
Artigo
Inglês
| MEDLINE | ID: mdl-24798819
15.
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.
ACS Chem Biol
; 9(10): 2334-46, 2014 Oct 17.
Artigo
Inglês
| MEDLINE | ID: mdl-25137254
16.
Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.
ACS Chem Neurosci
; 4(8): 1217-28, 2013 Aug 21.
Artigo
Inglês
| MEDLINE | ID: mdl-23682684
17.
Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273.
ChemMedChem
; 4(4): 505-11, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19197923
18.
Cytoskeletal requirements for hepatitis C virus (HCV) RNA synthesis in the HCV replicon cell culture system.
J Virol
; 77(7): 4401-8, 2003 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-12634397
19.
Discovery of a novel bicycloproline P2 bearing peptidyl alpha-ketoamide LY514962 as HCV protease inhibitor.
Bioorg Med Chem Lett
; 14(1): 251-6, 2004 Jan 05.
Artigo
Inglês
| MEDLINE | ID: mdl-14684337