Detalhe da pesquisa
1.
Hsa-miRNA-23a-3p promotes atherogenesis in a novel mouse model of atherosclerosis.
J Lipid Res
; 61(12): 1764-1775, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33008925
2.
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature
; 504(7480): 437-40, 2013 Dec 19.
Artigo
Inglês
| MEDLINE | ID: mdl-24226772
3.
A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice.
Lipids Health Dis
; 13: 167, 2014 Oct 31.
Artigo
Inglês
| MEDLINE | ID: mdl-25361754
4.
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings.
Nat Metab
; 6(2): 290-303, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38316982
5.
A transcriptomic and proteomic atlas of obesity and type 2 diabetes in cynomolgus monkeys.
Cell Rep
; 42(8): 112952, 2023 08 29.
Artigo
Inglês
| MEDLINE | ID: mdl-37556324
6.
An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice.
J Lipid Res
; 53(4): 643-52, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22287724
7.
GIPR gene expression in testis is mouse specific and can impact male mouse fertility.
Andrology
; 10(4): 789-799, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35224888
8.
Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.
J Pharmacol Exp Ther
; 338(1): 70-81, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21471191
9.
Growth differentiation factor 15 as a potential therapeutic for treating obesity.
Mol Metab
; 46: 101117, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33220493
10.
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.
Cell Rep Med
; 2(5): 100263, 2021 05 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34095876
11.
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor.
Am J Physiol Endocrinol Metab
; 299(4): E624-32, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20647556
12.
Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies for the Treatment of Obesity, Do Agonists = Antagonists?
Endocr Rev
; 41(1)2020 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31511854
13.
The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15.
PLoS One
; 15(8): e0231234, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32804947
14.
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism.
Nat Commun
; 11(1): 4981, 2020 10 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33020469
15.
Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.
MAbs
; 12(1): 1710047, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-31905038
16.
Cardiovascular response to small-molecule APJ activation.
JCI Insight
; 5(8)2020 04 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32208384
17.
An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice.
Mol Pharmacol
; 75(4): 901-7, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19129426
18.
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Am J Physiol Endocrinol Metab
; 297(5): E1105-14, 2009 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19706786
19.
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia.
J Pharmacol Exp Ther
; 331(3): 871-81, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19720878
20.
Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys.
J Pharmacol Exp Ther
; 329(1): 102-11, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19129372