Detalhe da pesquisa
1.
Cryo-EM structures of functional and pathological amyloid ribonucleoprotein assemblies.
Trends Biochem Sci
; 49(2): 119-133, 2024 02.
Artigo
Inglês
| MEDLINE | ID: mdl-37926650
2.
Is a cure for Parkinson's disease hiding inside us?
Trends Biochem Sci
; 47(8): 641-644, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35193796
3.
Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence.
Plant Cell
; 35(9): 3325-3344, 2023 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37401663
4.
Aggrescan4D: structure-informed analysis of pH-dependent protein aggregation.
Nucleic Acids Res
; 2024 May 13.
Artigo
Inglês
| MEDLINE | ID: mdl-38738618
5.
A3D Model Organism Database (A3D-MODB): a database for proteome aggregation predictions in model organisms.
Nucleic Acids Res
; 52(D1): D360-D367, 2024 Jan 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37897355
6.
Correction: Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis.
PLoS Genet
; 18(5): e1010216, 2022 May.
Artigo
Inglês
| MEDLINE | ID: mdl-35533143
7.
A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion.
J Am Chem Soc
; 146(18): 12702-12711, 2024 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38683963
8.
Effect of the aggregated protein dye YAT2150 on Leishmania parasite viability.
Antimicrob Agents Chemother
; 68(3): e0112723, 2024 Mar 06.
Artigo
Inglês
| MEDLINE | ID: mdl-38349159
9.
Advances, challenges, and opportunities in structural biology.
Trends Biochem Sci
; 49(2): 93-96, 2024 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38199894
10.
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.
J Biol Chem
; 298(5): 101902, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35390347
11.
A3D database: structure-based predictions of protein aggregation for the human proteome.
Bioinformatics
; 38(11): 3121-3123, 2022 05 26.
Artigo
Inglês
| MEDLINE | ID: mdl-35445695
12.
A3DyDB: exploring structural aggregation propensities in the yeast proteome.
Microb Cell Fact
; 22(1): 186, 2023 Sep 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37716955
13.
Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
J Biol Chem
; 297(3): 101039, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34343569
14.
SolupHred: a server to predict the pH-dependent aggregation of intrinsically disordered proteins.
Bioinformatics
; 37(11): 1602-1603, 2021 07 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33098409
15.
Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation.
Int J Mol Sci
; 23(23)2022 Nov 27.
Artigo
Inglês
| MEDLINE | ID: mdl-36499173
16.
Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses.
Hum Mol Genet
; 28(1): 1-15, 2019 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30215702
17.
Functionalized Prion-Inspired Amyloids for Biosensor Applications.
Biomacromolecules
; 22(7): 2822-2833, 2021 07 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34196531
18.
Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability.
Bioorg Chem
; 117: 105472, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34775206
19.
Aggrescan3D (A3D) 2.0: prediction and engineering of protein solubility.
Nucleic Acids Res
; 47(W1): W300-W307, 2019 07 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31049593
20.
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
Proc Natl Acad Sci U S A
; 115(41): 10481-10486, 2018 10 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30249646