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J Pharm Pharmacol ; 49(4): 397-402, 1997 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9232537

RESUMO

Differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM) have been used to determine the influence of beta-cyclodextrin (beta-CyD), hydroxypropyl-beta-CyD (HP-beta-CyD) and gamma-CyD on the structural properties of the stratum corneum from the hairless mouse. Some modest changes in the stratum corneum lipid transition temperature were induced by HP-beta-CyD and blue shifts were observed in the FTIR spectra of the C-H asymmetric and symmetric stretching of the lipids from the stratum corneum. Results from TEM studies indicated that HP-beta-CyD caused removal and possible disorganization of the lipid matrix that envelopes the corneocytes of the stratum corneum, whereas no effect was seen after treatment of the samples with beta-CyD and gamma-CyD. These results suggest that HP-beta-CyD can increase the permeability of the stratum corneum possibly as a result of extraction of lipids, and might thus enhance drug permeation through the skin.


Assuntos
Ciclodextrinas/farmacologia , Epiderme/efeitos dos fármacos , beta-Ciclodextrinas , gama-Ciclodextrinas , 2-Hidroxipropil-beta-Ciclodextrina , Animais , Varredura Diferencial de Calorimetria , Epiderme/metabolismo , Epiderme/ultraestrutura , Metabolismo dos Lipídeos , Masculino , Camundongos , Camundongos Pelados , Microscopia Eletrônica , Permeabilidade/efeitos dos fármacos , Pele/efeitos dos fármacos , Pele/metabolismo , Pele/ultraestrutura , Espectroscopia de Infravermelho com Transformada de Fourier
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