RESUMO
Three patients with focal brain-stem oculomotor disturbances (nuclear sixth nerve syndrome, sixth nerve palsy, bilateral internuclear ophthalmoplegia) as a consequence of multiple sclerosis have been studied with high-volume delayed computed tomography and high-field magnetic resonance imaging. In all of them, high-volume delayed computed tomography was inconclusive in the brain stem, but magnetic resonance imaging showed an area of prolonged T1 and/or T2 in the region appropriate to the oculomotor findings. Magnetic resonance imaging is the imaging technique of choice of small plaques in the brain stem. It can considerably aid clinicotopographic correlation in multiple sclerosis.
Assuntos
Tronco Encefálico , Espectroscopia de Ressonância Magnética , Esclerose Múltipla/diagnóstico , Oftalmoplegia/diagnóstico , Adulto , Movimentos Oculares , Feminino , Humanos , Masculino , Esclerose Múltipla/fisiopatologiaRESUMO
The radiation dose to the lung from the administration of Tc-99m sulfur colloid aerosol (for ventilation investigations) has been calculated. The dose to the ciliated airway epithelium varies between 0.34 to 2.5 rads, compared with 0.31 rads to the lung parenchyma. The calculation was normalized to a total of 1 mCi of Tc-99m deposited in the lung.
Assuntos
Pulmão , Doses de Radiação , Enxofre/administração & dosagem , Tecnécio/administração & dosagem , Aerossóis , Humanos , Testes de Função Respiratória , Coloide de Enxofre Marcado com Tecnécio Tc 99mRESUMO
Pulmonary edema was produced in four anesthetized dogs by saline lavage. The animals were maintained by assisted ventilation with O2/halothane and examined by a nuclear magnetic resonance (NMR) 0.15T resistive-magnet imager. The distribution of edematous fluid was clearly observed. Image contrast increased with prolongation of the cycle time (TR). Tomographic maps of spin-lattice relaxation times (T1) of the lungs were calculated from the NMR images. Comparison of T1 values with gravimetric measurements of water content of lung samples showed significant correlation (r = .7, P less than .02, n = 12) suggesting a potential for in vivo lung water quantitation by NMR imaging. This in vivo correlation is qualitatively similar to the in vitro correlation. Accurate in vivo determinations of pulmonary T2 values may require respiratory gating.
Assuntos
Água Corporal/análise , Pulmão/patologia , Espectroscopia de Ressonância Magnética , Edema Pulmonar/diagnóstico , Animais , Cães , Pulmão/análise , Tamanho do Órgão , Oxigênio/sangue , Edema Pulmonar/sangueRESUMO
An in vivo magnetic resonance imaging (MRI) technique for identification and characterization of atherosclerotic plaque was assessed in animal and human models. Atherosclerosis was induced in the abdominal aorta of four rabbits by a combination of balloon denudation and a high cholesterol diet. In vivo conventional spin-echo and fat/water suppressed images of the rabbit aortae were obtained at 1.5 T. Chemical shift imaging (CSI) was achieved using a hybridization of selective excitation and modified Dixon techniques. These techniques were then used to obtain images of atherosclerotic lesions in the carotid arteries of four patients prior to endarterectomy. The MRI results were corroborated by histologic and high-resolution proton MR spectroscopic (8.5 T) analysis of rabbit aorta, human carotid endarterectomy, and six additional human superficial femoral and iliac atherectomy specimens. All animal and human lesions were classified as either fatty streaks or fibrotic plaque. When compared to conventional spin-echo images, fat suppression by CSI substantially improved the measured contrast-to-noise ratio between plaque and vessel lumen, and enhanced its discrimination from periadventitial fat. In contrast, water suppression eliminated visualization of plaque due to the negligible amount of isotropic (liquid-like) signal from the immobilized lesion lipids. Magnetic resonance spectroscopy corroborated the CSI results by demonstrating broad, ill-defined fat resonances characteristic of nonmobile lipids in both human and rabbit atherosclerotic lesions. These findings indicate that in vivo MRI of plaque is technically feasible and can be markedly improved using chemical shift imaging.
Assuntos
Arteriosclerose/diagnóstico , Imageamento por Ressonância Magnética , Espectroscopia de Ressonância Magnética , Animais , Aorta/patologia , Arteriosclerose/patologia , Artérias Carótidas/patologia , Humanos , Técnicas In Vitro , CoelhosRESUMO
In vitro animal and human models were used to evaluate the potential of chemical shift magnetic resonance imaging (MRI) for assessing fatty liver. Phantoms of varying fat content were created from mayonnaise-agar preparations. Fatty liver was induced in eight rats by feeding them ethanol for three to six weeks (36% of total calories), whereas eight control rats were fed a normal diet. T1-weighted in-phase and opposed-phase MR images were obtained of the phantoms animals, and 28 human subjects. Additional images obtained in animals included long TR images with in-phase and opposed-phase technique, and hybrid chemical shift water and fat suppression. The rats were killed and histologic status was graded blindly by a hepatopathologist as normal, mild, moderate, or severe fatty change, for correlation with MR grading. Quantitative analysis of MR images included fat signal fraction for animals, and relative signal decrease between in-phase and opposed-phase images for phantom and human data. Phantom in-phase signal increased linearly with respect to fat content, whereas opposed-phase signal decreased linearly. MRI and histologic grading of rat livers were highly correlated, especially when based on water suppression images (r = 0.91, P = .0001). Opposed-phase images were also highly correlated, while fat suppression images were less effective. There was no overlap between MR-derived fat fractions for control (2.6%-5.7%) versus ethanol-fed rats (7.7%-17.9%, P = .0002). Human liver considered to be fatty by visual inspection (n = 8) had higher relative signal decrease than nonfatty liver (n = 22) (P less than .001). Phantom, animal, and human data demonstrate that comparison of T1-weighted in-phase and opposed-phase images is both practical and sensitive in the detection and grading of fatty liver.
Assuntos
Fígado Gorduroso/diagnóstico , Fígado/patologia , Imageamento por Ressonância Magnética , Adulto , Idoso , Animais , Fígado Gorduroso Alcoólico/diagnóstico , Feminino , Humanos , Fígado/anatomia & histologia , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Modelos Estruturais , Ratos , Ratos EndogâmicosRESUMO
Studies were carried out on 11 habitual cigarette smokers to ascertain whether there was a difference in the regional deposition of particles during cigarette smoking compared with tidal breathing and also to investigate whether the ventilatory maneuvers associated with smoking influence the deposition site. A cigarette holder was constructed that permitted cigarette smoke to mix with a radioaerosol. An added resistance simulated the airflow resistance present in a filter-tipped cigarette. Respiratory patterns for the control period of tidal breathing and during smoking were monitored with a respiratory inductance plethysmograph. Smoking resulted in greater apical and central deposition than expected from the distribution of resting ventilation. The changes in the site of deposition during smoking are probably influenced mainly by the properties of the particles concerned, namely, its size, reactivity, and hygroscopicity. Changes in respiratory patterns that occur during inhalation of cigarette smoke may also have an effect but are difficult to quantify and show marked intersubject variation. In selected subjects smoking caused apical deposition to exceed that of the lower zones.
Assuntos
Pulmão/análise , Fumar , Adulto , Aerossóis , Humanos , Pletismografia , Respiração , Volume de Ventilação PulmonarRESUMO
BACKGROUND AND PURPOSE: Although research with functional MR imaging of the brain has proliferated over the past 5 years, technical limitations, such as motion, chemical shift, and susceptibility artifacts, have impeded such research in the human spinal cord. The purpose of this investigation was to determine whether a reliable functional MR imaging signal can be elicited from the cervical spinal cord during simple motor activity. METHODS: Subjects performed three different motor tasks that activate different segments of the spinal cord. Gradient-echo-planar imaging on a 1.5-T clinical unit was used to image cervical spinal cords of human subjects. Another group of subjects was imaged while performing isometric exercise to study the relationship between the blood oxygenation level-dependent (BOLD) signal and applied force. RESULTS: Task-dependent BOLD activity was detected in all subjects. Signal amplitude varied between 0.5% and 7%. Moreover, a linear relationship was found between the applied force and the signal amplitude during isometric exercise. While regions of activation were distributed throughout the spinal cord, concentrated activity was found in the anatomic locations of expected motor innervation. CONCLUSION: The functional MR imaging signal can be reliably detected with motor activity in the human cervical spinal cord on a 1.5-T clinical unit. The location of neural activation has an anatomic correspondence to the myotome in use. The strength of the BOLD signal is directly proportional to the level of muscular activity.
Assuntos
Imageamento por Ressonância Magnética , Medula Espinal/anatomia & histologia , Medula Espinal/fisiologia , Vértebras Cervicais , HumanosRESUMO
Small infarctions of the medulla produce typical neurologic deficits and can be clinically recognized fairly reliably. High-field magnetic resonance imaging with a 1.5 T prototype scanner successfully demonstrated very tiny medulla infarctions in three of five patients. These lesions were imaged readily by a fairly rapid (approximately 1-2 min scan time) partial-saturation technique and confirmed on multiple spin-echo images. In addition, in two cases vertebral occlusion ipsilateral to the infarction was suggested by high signal on T2 weighted spin-echo images.
Assuntos
Infarto Cerebral/diagnóstico , Espectroscopia de Ressonância Magnética , Bulbo , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The examination of the knee has rapidly become the most important non-neurologic application of MR imaging. The widespread availability of high signal-to-noise knee coils has made routine imaging with T2-weighted sequences in both coronal and sagittal planes possible in 30 minutes. The spin-echo sequence remains the most important imaging technique, although many newer sequences have also been applied to the knee, with varying degrees of success. Important pitfalls in diagnosis, such as high signal intensity in the posterior horn of the medial meniscus and the transverse meniscal ligament, displaced buckethandle meniscal tears, and discoid menisci, can be recognized with experience. Common clinical problems that are encountered include meniscal cysts, osteonecrosis, and bone bruises. Detection of subtle injuries of the medial collateral ligament, patellar tendon, and anterior cruciate ligament requires careful observation. Intra-articular loose bodies can be reliably detected with MR imaging, and it should be recognized that localized pigmented villonodular synovitis can sometimes simulate the appearance of a loose body. MR imaging is a valuable noninvasive procedure that is complementary to arthroscopy in the evaluation of diseases of the knee.
Assuntos
Artropatias/diagnóstico , Traumatismos do Joelho/diagnóstico , Imageamento por Ressonância Magnética , Humanos , Corpos Livres Articulares/diagnóstico , Cisto Sinovial/diagnóstico , Tendinopatia/diagnóstico , Lesões do Menisco TibialRESUMO
In imaging small anatomical parts such as the pituitary fossa, thin sections enhance the spatial resolution. Gradient recalled images (GRASS) using three-dimensional volume data produce ultrathin contiguous sections with a high signal-to-noise ratio. In this study, conventional spin-echo magnetic resonance images (MRIs) of the pituitary fossa were compared to three-dimensional gradient recalled MRI in 5 volunteers and 10 patients suspected of having pituitary gland abnormalities. Utility of fat suppression was also assessed, along with gadolinium enhancement. Conventional spin-echo and three-dimensional spoiled GRASS images, three-dimensional spoiled GRASS images without and with fat suppression (Group II), and three-dimensional spoiled GRASS images with fat suppression before and after gadolinium enhancement were compared. Three-dimensional spoiled GRASS images provided better delineation of the pituitary fossa structures. There was differential enhancement between the normal gland and pituitary tumors. The fat suppression technique following gadolinium administration helped separate the high signal of tumor from the high signal of the clivus marrow. In conclusion, T1-weighted three dimensional gradient-echo images with fat suppression following gadolinium enhancement appear promising in evaluation.
Assuntos
Meios de Contraste , Imageamento por Ressonância Magnética/métodos , Hipófise/patologia , Adenoma/diagnóstico , Adenoma/patologia , Síndrome da Sela Vazia/diagnóstico , Síndrome da Sela Vazia/patologia , Gadolínio , Humanos , Lipídeos , Ácido Pentético , Neoplasias Hipofisárias/diagnóstico , Neoplasias Hipofisárias/patologiaRESUMO
High resolution thin section (1.5 mm thick) spin echo images (HRSE) with narrow bandwidth of TMJ were compared to the conventional (3 mm thick) spin echo images (CSE) in 20 symptomatic patients. Our results revealed that the disk delineation was superior with HRSE and the degree of confidence in making the diagnosis was significantly higher with HRSE than with CSE. Narrow bandwidth, high resolution spin echo technique offers better anatomic detail in the TMJ, resulting in improved degree of confidence, without penalty in additional imaging time.
Assuntos
Imageamento por Ressonância Magnética/métodos , Transtornos da Articulação Temporomandibular/diagnóstico , Humanos , Estudos Prospectivos , Transtornos da Articulação Temporomandibular/epidemiologiaRESUMO
We have developed a novel in vivo proton MR spectroscopy magnetization transfer method for detection of lactate in ischemic tissue in the presence of interfering fat proton resonances. Pyruvate is magnetically labeled with a saturation pulse and, when converted to lactate, the lactate retains the label. Difference of spectra obtained with and without a saturation pulse contain no fat resonances. High-resolution spectra (determined with a GE 1.5 T Signa) of low lactate levels were obtained in vivo by water suppression using a 2662 composite RF pulse and slice-selective gradients. Spectral subtraction was performed in real time allowing the monitoring of a buildup of the intensity of the lactate peak. Pyruvate-lactate saturation transfer techniques should find wide applicability in the study of ischemia.
Assuntos
Lactatos/metabolismo , Imageamento por Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética/métodos , Humanos , Isquemia/metabolismo , Modelos Estruturais , Piruvatos , Técnica de SubtraçãoRESUMO
The objective of the study was to compare hybrid opposed-phase fat suppressed sequences using gradient-echo (GRE) and spin-echo (SE) techniques. Eight normal volunteers had abdominal imaging at 1.5 T using both an opposed-phase fat-suppressed SE sequence (TR/TE 450/14) and an opposed phase GRE sequence (TE = 2.5) with frequency-selective fat suppression. Signal to noise ratios (SNR) and contrast to noise ratios (CNR) relative to fat of pancreas, liver and paraspinal muscle were calculated for each sequence. The GRE sequence with TR of 150 (25 s breath-hold) significantly outperformed the corresponding 3 min SE sequence for SNR and CNR for all tissues (p < .05). Hybrid opposed-phase fat-suppressed GRE sequences can be performed with breath-holding in less overall imaging time than SE sequences, and can achieve superior fat suppression and signal-to-noise if sufficient TR is used.
Assuntos
Imageamento por Ressonância Magnética/métodos , Abdome/anatomia & histologia , Tecido Adiposo/anatomia & histologia , Adulto , HumanosRESUMO
The purpose of this work was to optimize and increase the accuracy of tissue segmentation of the brain magnetic resonance (MR) images based on multispectral 3D feature maps. We used three sets of MR images as input to the in-house developed semi-automated 3D tissue segmentation algorithm: proton density (PD) and T2-weighted fast spin echo and, T1-weighted spin echo. First, to eliminate the random noise, non-linear anisotropic diffusion type filtering was applied to all the images. Second, to reduce the nonuniformity of the images, we devised and applied a correction algorithm based on uniform phantoms. Following these steps, the qualified observer "seeded" (identified training points) the tissue of interest. To reduce the operator dependent errors, cluster optimization was also used; this clustering algorithm identifies the densest clusters pertaining to the tissues. Finally, the images were segmented using k-NN (k-Nearest Neighborhood) algorithm and a stack of color-coded segmented images were created along with the connectivity algorithm to generate the entire surface of the brain. The application of pre-processing optimization steps substantially improved the 3D tissue segmentation methodology.
Assuntos
Mapeamento Encefálico/instrumentação , Encéfalo/patologia , Processamento de Imagem Assistida por Computador/instrumentação , Imageamento por Ressonância Magnética/instrumentação , Anisotropia , Difusão , Imagem Ecoplanar/instrumentação , Humanos , Aumento da Imagem/instrumentação , Esclerose Múltipla/diagnóstico , Sensibilidade e EspecificidadeRESUMO
For a given TR and TE, image quality changes when the number of spin echoes obtained is varied. To investigate the importance of this in clinical imaging, a total of 4 patients and 9 volunteers had MRI examinations of the abdomen (n = 7) and/or pelvis (n = 8) which included at least 2 sequences with identical TR (2000 or 2500 ms), TE (80 ms) and other parameters, but with a different series of refocusing pulses. Sequences included single-echo (S), asymmetric and symmetric double-echo (AD and SD) and quadruple-echo (Q) techniques. Image contrast and severity of motion-induced artifact was measured via blind examination by 3 independent MRI radiologists and calculation of signal-difference, signal-difference-to-noise ratios and intensity of motion-induced "ghost artifact." The order of decreasing signal differences was S, SD, AD and Q, and all of three liver lesions were better seen with S than with SD techniques. These observations are consistent with signal loss from cumulative inaccuracies from multiple 180 degrees RF pulses. The order of increasing intensity of ghost artifact was Q, SD, AD and S, consistent with the beneficial motion artifact-reducing effects of even-echo rephasing. Knowledge of these effects of multi-echo imaging allows one to make informed decisions about imaging protocols rather than to simply obtain multiple echoes "because they are free."
Assuntos
Abdome/anatomia & histologia , Imageamento por Ressonância Magnética/métodos , Pelve/anatomia & histologia , Tecido Adiposo/anatomia & histologia , Neoplasias Colorretais/diagnóstico , Humanos , Aumento da Imagem , Rim/anatomia & histologia , Hepatopatias/diagnóstico , UrinaRESUMO
Conventional "proton density" and "T2-weighted" spin-echo images are susceptible to motion induced artifact, which is exacerbated by lipid signals. Gradient moment nulling can reduce motion artifact but lengthens the minimum TE, degrading the "proton density" contrast. We designed a pulse sequence capable of optimizing proton density and T2-weighted contrast while suppressing lipid signals and motion induced artifacts. Proton density weighting was obtained by rapid readout gradient reversal immediately after the excitation RF pulse, within a conventional spin-echo sequence. By analyzing the behavior of the macroscopic magnetization and optimizing excitation flip angle, we suppressed T1 contribution to the image, thereby enhancing proton density and T2-weighted contrast with a two- to four-fold reduction of repetition time. This permitted an increased number of averages to be used, reducing motion induced artifacts. Fat suppression in the presence of motion was investigated in two groups of 8 volunteers each by (i) modified Dixon technique, (ii) selective excitation, and (iii) hybrid of both. Elimination of fat signal by the first technique was relatively uniform across the field of view, but it did not fully suppress the ghosts originating from fat motion. Selective excitation, while sensitive to the main field inhomogeneity, largely eliminated the ghosts (0.21 +/- 0.05 vs. 0.29 +/- 0.06, p less than 0.01). The hybrid of both techniques combined with bandwidth optimization, however, showed the best results (0.17 +/- 0.04, p less than 0.001). Variable flip-angle imaging allows optimization of image contrast which, along with averaging and effective fat suppression, significantly improves gradient- and spin-echo imaging, particularly in the presence of motion.
Assuntos
Tecido Adiposo , Lipídeos , Imageamento por Ressonância Magnética/métodos , Humanos , Aumento da Imagem , Fígado/anatomia & histologia , Prótons , Baço/anatomia & histologiaRESUMO
The effects of varying the inversion or excitation RF pulse flip angles on image contrast and imaging time have been investigated in IR imaging theoretically, with phantoms and with normal volunteers. Signal intensity in an IR pulse sequence as a function of excitation, inversion and refocusing pulse flip angles was calculated from the solution to the Bloch equations and was utilized to determine the contrast behavior of a lesion/liver model. Theoretical and experimental results were consistent with each other. With the TI chosen to suppress the fat signal, optimization of the excitation pulse flip angle results in an increase in lesion/liver contrast or allows reduction in imaging time which, in turn, can be traded for an increased number of averages. This, in normal volunteers, improved spleen/liver contrast-to-noise ratio (9.0 vs. 5.7, n = 8, p less than 0.01) and suppressed respiratory ghosts by 33% (p less than 0.01). Reducing or increasing the inversion pulse from 180 degrees results in shorter TI needed to null the signal from the tissue of interest. Although this decreases the contrast-to-noise ratio, it can substantially increase the number of sections which can be imaged per given TR in conventional IR imaging or during breathold in the snapshot IR (turboFLASH) technique. Thus, the optimization of RF pulses is useful in obtaining faster IR images, increasing the contrast and/or increasing the number of imaging planes.
Assuntos
Imageamento por Ressonância Magnética/métodos , Abdome/anatomia & histologia , Tecido Adiposo/anatomia & histologia , Humanos , Fígado/anatomia & histologia , Modelos Estruturais , Baço/anatomia & histologia , Fatores de TempoRESUMO
Long TR/double spin-echo magnetic resonance images of the knee were obtained with and without the use of fat suppression techniques in seven patients with high signal intramedullary lesions. Comparison between images was performed qualitatively and quantitatively. Contrast-to-noise ratios between focal defects and surrounding fatty marrow were higher with fat suppression in all cases. The mean contrast-to-noise ratio for images obtained with fat suppression was 53.6, while for images obtained without fat suppression the mean contrast-to-noise ratio was 17.3 (p less than 0.01).
Assuntos
Medula Óssea/patologia , Traumatismos do Joelho/diagnóstico , Imageamento por Ressonância Magnética/métodos , Tecido Adiposo , Humanos , Aumento da Imagem/métodos , Traumatismos do Joelho/patologiaRESUMO
Magnetic resonance imaging is the method of choice for non-invasive detection and evaluation of tumors of the central nervous system. However, discrimination of tumor boundaries from normal tissue, and the evaluation of heterogeneous lesions have proven to be limitations in traditional magnetic resonance imaging. The use of post-image acquisition processing techniques, such as multispectral tissue segmentation analysis, may provide more accurate clinical information. In this report, we have employed an experimental animal model for brain tumors induced by glial cells transformed by the human neurotropic JC virus to examine the utility of multispectral tissue segmentation for tumor cell identification. Six individual tissue types were discriminated by segmentation analysis, including heterogeneous tumor tissue, a clear demarcation of the boundary between tumor and non-tumor tissue, deep and cortical gray matter, and cerebrospinal fluid. Furthermore, the segmentation analysis was confirmed by histopathological evaluation. The use of multispectral tissue segmentation analysis may optimize the non-invasive determination and volumetric analysis of CNS neoplasms, thus providing improved clinical evaluation of tumor growth and evaluation of the effectiveness of therapeutic treatments.
Assuntos
Neoplasias Encefálicas/diagnóstico , Encéfalo/patologia , Imageamento por Ressonância Magnética , Neoplasias Experimentais/diagnóstico , Animais , Animais Recém-Nascidos , Cricetinae , Glioma/patologia , Transplante de Neoplasias , Reprodutibilidade dos Testes , Células Tumorais Cultivadas/transplanteRESUMO
Using experimentally induced pulmonary emboli in an animal model, three intravenously administered contrast agents, Gd-DTPA-albumin microspheres (8-15 microns, 0.2 M particles/mg protein, 39-106 micrograms Gd/mg, 50 mg/ml), Gd-DTPA-liposomes (15-30 microns, 130 micrograms/mg lipid, 6 mg Gd/ml) and superparamagnetic ferrosome, (60 nm, 100 mM iron and 20 mg lipid/ml) were examined for MR imaging. Gd-DTPA entrapped in lung capillaries did not enhance the signal intensity of lung parenchyma, but liposomes (5 ml) served as better Gd-DTPA carriers and increased the parenchymal signal intensity by up to a factor of 2.3. However, neither agent improved delineation of pulmonary emboli. Ferrosome decreased the intensity of lung parenchyma, improving detectability of pulmonary emboli by several factors.