Detalhe da pesquisa
1.
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers.
Gut
; 70(9): 1632-1641, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33199443
2.
A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.
Br J Cancer
; 123(4): 542-555, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32439931
3.
Inhibitors in AKTion: ATP-competitive vs allosteric.
Biochem Soc Trans
; 48(3): 933-943, 2020 06 30.
Artigo
Inglês
| MEDLINE | ID: mdl-32453400
4.
Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients.
PLoS Comput Biol
; 14(1): e1005924, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29293494
5.
IQGAP1 controls tight junction formation through differential regulation of claudin recruitment.
J Cell Sci
; 128(5): 853-62, 2015 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25588839
6.
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.
Cancer Cell
; 11(6): 555-69, 2007 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-17560336
7.
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death.
Mol Syst Biol
; 8: 589, 2012 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-22735335
8.
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Proc Natl Acad Sci U S A
; 107(14): 6459-64, 2010 Apr 06.
Artigo
Inglês
| MEDLINE | ID: mdl-20308550
9.
HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.
Cancer Cell
; 6(5): 517-27, 2004 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-15542435
10.
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Proc Natl Acad Sci U S A
; 106(23): 9435-40, 2009 Jun 09.
Artigo
Inglês
| MEDLINE | ID: mdl-19478061
11.
Targeting un-MET needs in advanced non-small cell lung cancer.
Lung Cancer
; 164: 56-68, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35033939
12.
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF.
Life Sci Alliance
; 5(9)2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35580987
13.
Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine.
Pharmgenomics Pers Med
; 14: 1517-1535, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34858045
14.
Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency.
J Gen Virol
; 91(Pt 2): 463-9, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19864499
15.
Epidermal growth factor receptor inhibitors in oncology.
Curr Opin Oncol
; 22(6): 573-8, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-20739887
16.
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.
Proc Natl Acad Sci U S A
; 104(50): 20007-12, 2007 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-18077431
17.
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma.
J Clin Invest
; 130(11): 5875-5892, 2020 11 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33016930
18.
Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.
Cancer Res
; 67(13): 6083-91, 2007 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17616663
19.
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
N Engl J Med
; 353(19): 2012-24, 2005 Nov 10.
Artigo
Inglês
| MEDLINE | ID: mdl-16282176
20.
The phosphatidylinositol 3-Kinase AKT pathway in human cancer.
Nat Rev Cancer
; 2(7): 489-501, 2002 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-12094235