Detalhe da pesquisa
1.
APJ acts as a dual receptor in cardiac hypertrophy.
Nature
; 488(7411): 394-8, 2012 Aug 16.
Artigo
Inglês
| MEDLINE | ID: mdl-22810587
2.
Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1.
Proc Natl Acad Sci U S A
; 110(9): 3333-8, 2013 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-23341587
3.
The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans.
Crit Care Med
; 43(6): e199-202, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25978169
4.
A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.
Br J Clin Pharmacol
; 78(1): 69-77, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24446723
5.
Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.
Proc Natl Acad Sci U S A
; 106(1): 262-7, 2009 Jan 06.
Artigo
Inglês
| MEDLINE | ID: mdl-19116277
6.
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.
J Biol Chem
; 285(43): 32695-32703, 2010 Oct 22.
Artigo
Inglês
| MEDLINE | ID: mdl-20702418
7.
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
Proc Natl Acad Sci U S A
; 105(25): 8754-9, 2008 Jun 24.
Artigo
Inglês
| MEDLINE | ID: mdl-18559859
8.
Estrogen receptor beta agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: a pharmacogenomic study.
J Infect Dis
; 201(8): 1250-7, 2010 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20205571
9.
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.
J Lipid Res
; 50(12): 2358-70, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19318684
10.
GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs.
J Cardiovasc Pharmacol Ther
; 14(3): 207-14, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19721133
11.
Discovery of NV-5138, the first selective Brain mTORC1 activator.
Sci Rep
; 9(1): 4107, 2019 03 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30858438
12.
Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation.
J Clin Invest
; 129(6): 2542-2554, 2019 04 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30990795
13.
Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters.
Cell Chem Biol
; 26(9): 1203-1213.e13, 2019 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31231029
14.
Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation.
Thromb Haemost
; 99(2): 343-51, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18278184
15.
Inhibitors of Factor VIIa/tissue factor.
Arterioscler Thromb Vasc Biol
; 27(9): 1895-900, 2007 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-17600222
16.
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Nat Commun
; 9(1): 548, 2018 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29416044
17.
Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis.
Thromb Haemost
; 95(3): 469-75, 2006 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-16525575
18.
Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism.
Cancer Res
; 63(11): 2997-3000, 2003 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12782609
19.
PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.
Shock
; 45(4): 411-8, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26974318
20.
Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys.
Lancet
; 362(9400): 1953-8, 2003 Dec 13.
Artigo
Inglês
| MEDLINE | ID: mdl-14683653