Detalhe da pesquisa
1.
Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Hepatology
; 73(1): 53-67, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32246499
2.
Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes.
J Virol
; 93(16)2019 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31167911
3.
Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29866875
4.
Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by Phosphorylation.
J Virol
; 90(12): 5830-5844, 2016 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27076641
5.
Preclinical characterization of GSK2336805, a novel inhibitor of hepatitis C virus replication that selects for resistance in NS5A.
Antimicrob Agents Chemother
; 58(1): 38-47, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24126581
6.
Clinical and in vitro resistance to GS-9669, a thumb site II nonnucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Antimicrob Agents Chemother
; 58(11): 6599-606, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25155588
7.
In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor.
Antimicrob Agents Chemother
; 57(11): 5216-24, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23939896
8.
Woolly Monkey-HBV Infection in Squirrel Monkeys as a Surrogate Nonhuman Primate Model of HBV Infection.
Hepatol Commun
; 4(3): 371-386, 2020 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-32140655
9.
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.
J Med Chem
; 62(7): 3254-3267, 2019 04 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30763090
10.
A randomized, double blind, dose escalation, first time in human study to assess the safety, tolerability, pharmacokinetics, and antiviral activity of single doses of GSK2485852 in chronically infected hepatitis C subjects.
Clin Pharmacol Drug Dev
; 3(6): 439-48, 2014 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27129119
11.
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
J Med Chem
; 57(5): 1902-13, 2014 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-23672667
12.
Hepatitis C genotype 1a replicon improved through introduction of fitness mutations.
Biotechniques
; 52(4): 273-5, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22482443
13.
Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association.
Mol Cell
; 24(6): 877-89, 2006 Dec 28.
Artigo
Inglês
| MEDLINE | ID: mdl-17189190
14.
E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes.
J Virol
; 76(7): 3440-51, 2002 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-11884568