[Epidemiology of patients presenting to the emergency room for dyspnea in Belgium]. / Epidémiologie des patients se présentant aux urgences pour dyspnée en Belgique.

Studies about patients' profile presenting to the emergency department for dyspnea are scarce in Europe, and even more in Belgium. We analyze here a cohort of patients with acute dyspnea in three Belgian centers, as to the epidemiology of this dyspnea, the tests carried out, the diagnoses retained, the treatments administered, the hospitalization and survival rates. The secondary objective is to compare this Belgian cohort with a European population resulting from a large multicenter study. The analysis of 131 patients showed that acute dyspnea in the emergency department corresponds to four main diagnoses (exacerbation of chronic obstructive pulmonary disease, infections of the lower respiratory tract, acute cardiac decompensation and asthma). The age of patients is over 80 years in a quarter of them, the hospitalization rate is 57 % and the mortality is 5 %. Our analysis also reveals that the check of vital parameters may be insufficiently realized, as may the use of non-invasive ventilation. Etiological diagnoses made in the emergency department are confirmed at the end of hospitalization in 75 % of cases. The Belgian population is younger than the European population (62 against 69 years), presents fewer infection of the lower respiratory tract (20 % against 31 %), and is comparable to the European population for the other parameters studied. The article ends with 10 key messages that will enlighten clinicians about the reality of acute dyspnea in emergency rooms in Belgium.

Le profil des patients se présentant au service des urgences pour dyspnée est peu étudié en Europe, et encore moins en Belgique. Nous analysons ici une cohorte de patients présentant une dyspnée aiguë dans trois centres belges, quant à l'épidémiologie de cette dyspnée, les examens complémentaires réalisés, les diagnostics retenus, les traitements administrés, les taux d'hospitalisations et de survie. L'objectif secondaire est de comparer cette cohorte belge à une population européenne issue d'une vaste étude multicentrique. L'analyse de 131 patients révèle que la dyspnée aiguë au service des urgences correspond à quatre principaux diagnostics : l'exacerbation de bronchopneumopathie chronique obstructive, les infections des voies respiratoires inférieures, la décompensation cardiaque aiguë et l'asthme. L'âge des patients est supérieur à 80 ans chez un quart d'entre eux, le taux d'hospitalisation est de 57 % et la mortalité de 5 %. Notre analyse révèle également que la prise des paramètres vitaux peut être insuffisamment réalisée, tout comme le recours à la ventilation non invasive. Les diagnostics étiologiques posés dans le service des urgences sont confirmés en fin d'hospitalisation dans 75 % des cas. La population belge est plus jeune que la population européenne (62 versus 69 ans), présente moins souvent un diagnostic d'infection des voies respiratoires inférieures (20 % versus 31 %), et est comparable à la population européenne pour les autres paramètres étudiés. L'article évoque 10 messages-clés qui aideront les cliniciens à mieux percevoir la réalité de la dyspnée aiguë aux urgences en Belgique.

[Contribution of the Duke's classification in the emergency department in the early management of infective endocarditis]. / Apport de la classification de Duke au service des urgences dans la prise en charge précoce de l'endocardite infectieuse.

The diagnosis of infective endocarditis is based on multiple clinical signs than on a single positive test result. The contribution of echocardiography is an indispensable asset to avoid misdiagnosis or delayed correct diagnosis. A 24-year old woman is admitted to the emergency room. She has a poor general condition, pyrexia and necrotic lesions on the body. After examination, the diagnosis of multiple organ failure and severe sepsis from infective endocarditis from intravenous injections of cocaine is made and the patient is transferred to ICU. She is treated with vancomycin for 4 weeks and gentamicin for 8 days. Her clinical improvement allows her to be transferred to a hospital unit at day 6. She goes home after 28 days of hospitalization. Several sets of criteria for the diagnosis of infective endocarditis are described. The most commonly accepted are revised Duke's criteria that take into account echocardiography. This article aims, through a clinical case, to describe this classification too little used in the emergency room.

Comparison of different software implementations for spatial disease mapping.

Disease mapping is a scientific field that aims to understand and predict disease risk based on counts of observed cases within small regions of a study area of interest. Hierarchical model-based approaches that borrow information from neighbouring areas via conditional autoregressive (CAR) random effects on the local disease rates have gained a lot of popularity, thanks to the readily implemented Markov chain Monte Carlo methods. Nowadays, many software implementations to model risk distributions exist. Many of these applications differ, to varying degrees, in the underlying methodology. This paper provides an in-depth comparison between analysis results, coming from R-packages CARBayes, R2OpenBUGS, NIMBLE, R2BayesX, R-INLA, and RStan. We investigate CAR models typically used in disease mapping for spatially discrete count data. Data about diabetics in children and young adults in Belgium are used in a case study, while simulation studies are undertaken to assess software performance in different settings.

Anatomical relation of third molars and the retromolar canal.

The study was designed to assess, by direct anatomical observations and cone-beam computed tomography (CT), the prevalence of a retromolar canal and foramen in relation to the mandibular third molar in dry human mandibles. Dry mandibles from European skeletons (n=89) were observed directly and after cone-beam CT scanning (Newtom VGI evo). The following variables were assessed: the presence of a retromolar foramen and canal; the presence of a third molar, and orientation of the third molar. From the total of 89 mandibles selected, 73 showed a retromolar foramen (49 of which were bilateral). A retromolar canal was identified in 64 mandibles based on cone-beam CT assessment, with a total of 101 canals, including 74 that were bilateral. A total of 112 hemimandibles contained a third molar. Orientation of the third molar did not seem to indicate the presence of retromolar foramina or canals. A similar prevalence of retromolar canals was found for both vertically (41/79) and mesially (17/33) orientated third molars. A retromolar foramen and canal were present in most mandibles, with more than half being bilateral. We were unable to confirm a potential relation between the retromolar foramen and canal on the one hand, and the orientation of the third molar on the other.

Iatrogenic trigeminal post-traumatic neuropathy: a retrospective two-year cohort study.

With the growing demand for dental work, trigeminal nerve injuries are increasingly common. This retrospective cohort study examined 53 cases of iatrogenic trigeminal nerve injury seen at the Department of Oral and Maxillofacial Surgery, University Hospitals of Leuven between 2013 and 2014 (0.6% among 8845 new patient visits). Patient records were screened for post-traumatic trigeminal nerve neuropathy caused by nerve injury incurred during implant surgery, endodontic treatment, local anaesthesia, tooth extraction, or specifically third molar removal. The patients ranged in age from 15 to 80years (mean age 42.1years) and 68% were female. The referral delay ranged from 1day to 6.5years (average 10months). The inferior alveolar nerve (IAN) was most frequently injured (28 cases), followed by the lingual nerve (LN) (21 cases). Most nerve injuries were caused during third molar removal (24 cases), followed by implant placement (nine cases) and local anaesthesia injuries (nine cases). Pain symptoms were experienced by 54% of patients suffering IAN injury, compared to 10% of patients with LN injury. Persistent neurosensory disturbances were identified in 60% of patients. While prevention remains the key issue, timely referral seems to be a critical factor for the successful treatment of post-traumatic neuropathy.

Risks of flumazenil in mixed benzodiazepine-tricyclic antidepressant overdose: report of a preliminary study in the dog.

This preliminary study evaluates the cardiac and neurological risks associated with the sudden antagonism of benzodiazepine (BZD)--induced sedation in dogs intoxicated with tricyclic anti-depressants (TCA). Twelve dogs were anesthetized with midazolam and ventilated with room air. EEG, ECG, and arterial pressure were continuously recorded. An infusion of amitriptyline (6 dogs) or clomipramine (6 dogs) 1 mg/kg. min was maintained until signs of cardiotoxicity (QRS prolongation, hypotension or arrhythmias) occurred. The effects of a bolus of flumazenil 0.2 mg/kg were then observed until 120 minutes. In amitriptyline poisoning, BZD reversal was associated with development of convulsions in 3 dogs, with severe arrhythmias in 4 and with one death. In clomipramine intoxication, 2 dogs developed sudden fatal arrhythmias. These results show that BZD reversal may unmask the convulsant properties and increase the severity of arrhythmias induced by TCA.

Effect of PK11195 on cardiovascular toxicity due to verapamil: an experimental study in the dog.

In vitro studies have suggested that peripheral binding sites (PBR) for benzodiazepine (BZD) could be coupled to the voltage operated calcium channel (VOC) in the heart and that PK11195, an non-BZD ligand with antagonistic activity at this receptors, could inhibit the electrophysiological and mechanical properties of both "peripheral" benzodiazepines and calcium channel blockers. This study evaluates the antidotal value of PK11195 against the cardiovascular depression and arrhythmias in a canine model of acute verapamil intoxication. Although sinus activity is more often preserved or restored (7/8 vs 1/6) in the animals treated with PK11195, this compound, administered in doses able to saturate heart PBR, is unable to prevent or correct the haemodynamic alterations induced by acute verapamil intoxication and the improvement of survival (8/8 vs 3/6) is not significant.

Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.

This study evaluates the cardiac and neurologic risks associated with the antagonization of the benzodiazepine component of mixed drug overdoses, when cyclic antidepressants are also implicated. Twenty-four mongrel dogs were anesthetized and ventilated. Electroencephalogram, electrocardiogram, and tidal carbon dioxide and arterial pressure were continuously recorded. Amitriptyline (1 mg/kg/min) associated with midazolam (1 mg/kg + 1 mg/kg/h) was infused in 12 of the dogs. Midazolam was replaced by saline in the other 12. Drug administration was continued until signs of cardiotoxicity (QRS prolongation greater than 120 milliseconds or sustained arrhythmias) occurred. At that moment, midazolam effects were suddenly reversed by administration of flumazenil 0.2 mg/kg in six dogs out of each group. Placebo was administered in the others. Reactions were observed for the next 120 minutes. Midazolam-induced sedation efficiently protects (P less than .02) against seizures due to amitriptyline toxicity. This protective effect is counteracted by flumazenil. Midazolam has limited influence on the cardiac toxic effects of amitriptyline. The bolus of flumazenil is, however, associated with a significant worsening of electrocardiogram disturbances, and two sudden deaths were recorded. The mechanism of this effect remains unclear, as it could be unrelated to the antagonization of midazolam sedation. Given the problem of extrapolating animal data to humans, these results suggest that bolus administration of high doses of flumazenil in mixed intoxication implicating benzodiazepine and cyclic antidepressants has the potential to precipitate convulsions and/or arrhythmias. A slowly titrated administration of the antidote, as usually recommended, could prevent these effects.

The choice of fungi as test organisms in disinfectant testing.

In order to find out whether more than one test organism is needed for the determination of the activity of disinfectants towards mycelium-forming fungi and yeasts, eight different species of fungi and one yeast-like fungus were submitted to seven different disinfectants in varying concentrations. As Candida albicans was found to be the most resistant, the authors propose that only Candida albicans should be used.