Detalhe da pesquisa
1.
Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice.
Anal Bioanal Chem
; 405(8): 2635-42, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-23377112
2.
Localization and quantification of drugs in animal tissues by use of desorption electrospray ionization mass spectrometry imaging.
Anal Chem
; 84(12): 5439-45, 2012 Jun 19.
Artigo
Inglês
| MEDLINE | ID: mdl-22663341
3.
Identification of quinone imine containing glutathione conjugates of diclofenac in rat bile.
Chem Res Toxicol
; 23(12): 1947-53, 2010 Dec 20.
Artigo
Inglês
| MEDLINE | ID: mdl-21053927
4.
Desorption electrospray ionization tissue imaging using heated nebulizing gas and high-resolution accurate mass spectra.
Rapid Commun Mass Spectrom
; 24(16): 2352-6, 2010 Aug 30.
Artigo
Inglês
| MEDLINE | ID: mdl-20635324
5.
A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
Drug Metab Dispos
; 36(9): 1740-4, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18541695
6.
Synthesis and activity of substituted carbamates as potentiators of the alpha4beta2 nicotinic acetylcholine receptor.
Bioorg Med Chem Lett
; 18(20): 5643-7, 2008 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18805006
7.
Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.
Bioorg Med Chem Lett
; 18(19): 5209-12, 2008 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18789861
8.
DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice.
Brain Res
; 1048(1-2): 177-84, 2005 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-15925329
9.
Gender effects on rat metabolism of AMG 900, an orally available small molecule aurora kinase inhibitor.
Drug Metab Lett
; 5(4): 290-7, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-22022868
10.
Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.
J Med Chem
; 54(13): 4427-45, 2011 Jul 14.
Artigo
Inglês
| MEDLINE | ID: mdl-21634377
11.
Identification of a novel glutathione conjugate of diclofenac by LTQ-Orbitrap.
Drug Metab Lett
; 2(1): 35-40, 2008 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19356068
12.
Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile.
Drug Metab Dispos
; 31(11): 1327-36, 2003 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-14570764
13.
Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe.
Am J Physiol Endocrinol Metab
; 286(2): E252-60, 2004 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-14570702
14.
Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics.
J Biol Chem
; 278(24): 21972-9, 2003 Jun 13.
Artigo
Inglês
| MEDLINE | ID: mdl-12690106