Pesquisa | Secretaria de Estado da Saúde

1.

ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.

Hu, Shi-Bin; Heraud-Farlow, Jacki; Sun, Tao; Liang, Zhen; Goradia, Ankita; Taylor, Scott; Walkley, Carl R; Li, Jin Billy.

Mol Cell ; 83(21): 3869-3884.e7, 2023 Nov 02.

Artigo Inglês | MEDLINE | ID: mdl-37797622

2.

Generation of a new Adar1p150 ^-/- mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis.

Liang, Zhen; Goradia, Ankita; Walkley, Carl R; Heraud-Farlow, Jacki E.

RNA ; 29(9): 1325-1338, 2023 09.

Artigo Inglês | MEDLINE | ID: mdl-37290963

3.

The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant.

Liang, Zhen; Chalk, Alistair M; Taylor, Scott; Goradia, Ankita; Heraud-Farlow, Jacki E; Walkley, Carl R.

EMBO Rep ; 24(5): e55835, 2023 05 04.

Artigo Inglês | MEDLINE | ID: mdl-36975179

4.

Dynamic landscape and regulation of RNA editing in mammals.

Tan, Meng How; Li, Qin; Shanmugam, Raghuvaran; Piskol, Robert; Kohler, Jennefer; Young, Amy N; Liu, Kaiwen Ivy; Zhang, Rui; Ramaswami, Gokul; Ariyoshi, Kentaro; Gupte, Ankita; Keegan, Liam P; George, Cyril X; Ramu, Avinash; Huang, Ni; Pollina, Elizabeth A; Leeman, Dena S; Rustighi, Alessandra; Goh, Y P Sharon; Chawla, Ajay; Del Sal, Giannino; Peltz, Gary; Brunet, Anne; Conrad, Donald F; Samuel, Charles E; O'Connell, Mary A; Walkley, Carl R; Nishikura, Kazuko; Li, Jin Billy.

Nature ; 550(7675): 249-254, 2017 10 11.

Artigo Inglês | MEDLINE | ID: mdl-29022589

5.

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4.

Castillo-Tandazo, Wilson; Smeets, Monique F; Murphy, Vincent; Liu, Rui; Hodson, Charlotte; Heierhorst, Jörg; Deans, Andrew J; Walkley, Carl R.

PLoS Genet ; 15(7): e1008266, 2019 07.

Artigo Inglês | MEDLINE | ID: mdl-31276497

6.

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.

Hartner, Jochen C; Walkley, Carl R; Lu, Jun; Orkin, Stuart H.

Nat Immunol ; 10(1): 109-15, 2009 Jan.

Artigo Inglês | MEDLINE | ID: mdl-19060901

7.

Srsf2^P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells.

Smeets, Monique F; Tan, Shuh Ying; Xu, Jane Jialu; Anande, Govardhan; Unnikrishnan, Ashwin; Chalk, Alistair M; Taylor, Scott R; Pimanda, John E; Wall, Meaghan; Purton, Louise E; Walkley, Carl R.

Blood ; 132(6): 608-621, 2018 08 09.

Artigo Inglês | MEDLINE | ID: mdl-29903888

8.

ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.

Nakahama, Taisuke; Kato, Yuki; Kim, Jung In; Vongpipatana, Tuangtong; Suzuki, Yutaka; Walkley, Carl R; Kawahara, Yukio.

EMBO Rep ; 19(12)2018 12.

Artigo Inglês | MEDLINE | ID: mdl-30361393

9.

Defining the functions of adenosine-to-inosine RNA editing through hematology.

Heraud-Farlow, Jacki E; Chalk, Alistair M; Walkley, Carl R.

Curr Opin Hematol ; 26(4): 241-248, 2019 07.

Artigo Inglês | MEDLINE | ID: mdl-31033705

10.

Patience is a virtue.

Walkley, Carl R.

Blood ; 139(4): 481-482, 2022 01 27.

Artigo Inglês | MEDLINE | ID: mdl-35084474

11.

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.

Shi, Wei; Vu, Therese; Boucher, Didier; Biernacka, Anna; Nde, Jules; Pandita, Raj K; Straube, Jasmin; Boyle, Glen M; Al-Ejeh, Fares; Nag, Purba; Jeffery, Jessie; Harris, Janelle L; Bain, Amanda L; Grzelak, Marta; Skrzypczak, Magdalena; Mitra, Abhishek; Dojer, Norbert; Crosetto, Nicola; Cloonan, Nicole; Becherel, Olivier J; Finnie, John; Skaar, Jeffrey R; Walkley, Carl R; Pandita, Tej K; Rowicka, Maga; Ginalski, Krzysztof; Lane, Steven W; Khanna, Kum Kum.

Blood ; 129(18): 2479-2492, 2017 05 04.

Artigo Inglês | MEDLINE | ID: mdl-28270450

12.

Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice.

Shekhar, Tanmay M; Burvenich, Ingrid J G; Harris, Michael A; Rigopoulos, Angela; Zanker, Damien; Spurling, Alex; Parker, Belinda S; Walkley, Carl R; Scott, Andrew M; Hawkins, Christine J.

BMC Cancer ; 19(1): 924, 2019 Sep 14.

Artigo Inglês | MEDLINE | ID: mdl-31521127

13.

Osteosarcoma in the Post Genome Era: Preclinical Models and Approaches to Identify Tractable Therapeutic Targets.

Castillo-Tandazo, Wilson; Mutsaers, Anthony J; Walkley, Carl R.

Curr Osteoporos Rep ; 17(5): 343-352, 2019 10.

Artigo Inglês | MEDLINE | ID: mdl-31529263

14.

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Chandrakanthan, Vashe; Yeola, Avani; Kwan, Jair C; Oliver, Rema A; Qiao, Qiao; Kang, Young Chan; Zarzour, Peter; Beck, Dominik; Boelen, Lies; Unnikrishnan, Ashwin; Villanueva, Jeanette E; Nunez, Andrea C; Knezevic, Kathy; Palu, Cintia; Nasrallah, Rabab; Carnell, Michael; Macmillan, Alex; Whan, Renee; Yu, Yan; Hardy, Philip; Grey, Shane T; Gladbach, Amadeus; Delerue, Fabien; Ittner, Lars; Mobbs, Ralph; Walkley, Carl R; Purton, Louise E; Ward, Robyn L; Wong, Jason W H; Hesson, Luke B; Walsh, William; Pimanda, John E.

Proc Natl Acad Sci U S A ; 113(16): E2306-15, 2016 Apr 19.

Artigo Inglês | MEDLINE | ID: mdl-27044077

15.

Murine models of osteosarcoma: A piece of the translational puzzle.

Walia, Mannu K; Castillo-Tandazo, Wilson; Mutsaers, Anthony J; Martin, Thomas John; Walkley, Carl R.

J Cell Biochem ; 119(6): 4241-4250, 2018 06.

Artigo Inglês | MEDLINE | ID: mdl-29236321

16.

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.

Ng, Alvin J M; Walia, Mannu K; Smeets, Monique F; Mutsaers, Anthony J; Sims, Natalie A; Purton, Louise E; Walsh, Nicole C; Martin, T John; Walkley, Carl R.

PLoS Genet ; 11(4): e1005160, 2015 Apr.

Artigo Inglês | MEDLINE | ID: mdl-25859855

17.

Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation.

Martin, Sally K; Fitter, Stephen; Dutta, Ankit K; Matthews, Mary P; Walkley, Carl R; Hall, Michael N; Ruegg, Markus A; Gronthos, Stan; Zannettino, Andrew C W.

Stem Cells ; 33(4): 1359-65, 2015 Apr.

Artigo Inglês | MEDLINE | ID: mdl-25537496

18.

Developmental and species-divergent globin switching are driven by BCL11A.

Sankaran, Vijay G; Xu, Jian; Ragoczy, Tobias; Ippolito, Gregory C; Walkley, Carl R; Maika, Shanna D; Fujiwara, Yuko; Ito, Masafumi; Groudine, Mark; Bender, M A; Tucker, Philip W; Orkin, Stuart H.

Nature ; 460(7259): 1093-7, 2009 Aug 27.

Artigo Inglês | MEDLINE | ID: mdl-19657335

19.

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.

Dewamitta, Sita R; Joseph, Chacko; Purton, Louise E; Walkley, Carl R.

Br J Haematol ; 164(2): 280-5, 2014 Jan.

Artigo Inglês | MEDLINE | ID: mdl-24383846

20.

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.

Singbrant, Sofie; Wall, Meaghan; Moody, Jennifer; Karlsson, Göran; Chalk, Alistair M; Liddicoat, Brian; Russell, Megan R; Walkley, Carl R; Karlsson, Stefan.

Haematologica ; 99(4): 647-55, 2014 Apr.

Artigo Inglês | MEDLINE | ID: mdl-24415629

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