Detalhe da pesquisa
1.
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Mol Cell
; 78(6): 1152-1165.e8, 2020 06 18.
Artigo
Inglês
| MEDLINE | ID: mdl-32516598
2.
Targeted inhibition of gut bacterial ß-glucuronidase activity enhances anticancer drug efficacy.
Proc Natl Acad Sci U S A
; 117(13): 7374-7381, 2020 03 31.
Artigo
Inglês
| MEDLINE | ID: mdl-32170007
3.
Virtual Screening for the Discovery of Microbiome ß-Glucuronidase Inhibitors to Alleviate Cancer Drug Toxicity.
J Chem Inf Model
; 62(7): 1783-1793, 2022 04 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35357819
4.
APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress.
Proc Natl Acad Sci U S A
; 114(2): 304-309, 2017 01 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28028224
5.
Ribonucleotide triggered DNA damage and RNA-DNA damage responses.
RNA Biol
; 11(11): 1340-6, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25692233
6.
Molecular insights into microbial ß-glucuronidase inhibition to abrogate CPT-11 toxicity.
Mol Pharmacol
; 84(2): 208-17, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23690068
7.
Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective.
Drug Metab Rev
; 45(1): 79-100, 2013 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-23210723
8.
Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights.
Biochemistry
; 51(39): 7699-711, 2012 Oct 02.
Artigo
Inglês
| MEDLINE | ID: mdl-22954034
9.
Pharmacologic targeting of bacterial ß-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice.
J Pharmacol Exp Ther
; 341(2): 447-54, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22328575
10.
Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.
Cell Rep
; 41(1): 111448, 2022 10 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36198268
11.
Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis .
Biochemistry
; 49(38): 8398-414, 2010 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-20799687
12.
Targeting the pregnane X receptor using microbial metabolite mimicry.
EMBO Mol Med
; 12(4): e11621, 2020 04 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32153125
13.
Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus.
Protein Sci
; 25(9): 1682-91, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27345688
14.
Recognition and repair of chemically heterogeneous structures at DNA ends.
Environ Mol Mutagen
; 56(1): 1-21, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25111769
15.
Structure and Inhibition of Microbiome ß-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.
Chem Biol
; 22(9): 1238-49, 2015 Sep 17.
Artigo
Inglês
| MEDLINE | ID: mdl-26364932
16.
The human microbiome is a source of therapeutic drug targets.
Curr Opin Chem Biol
; 17(3): 379-84, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23680493
17.
Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα.
J Mol Biol
; 425(14): 2561-77, 2013 Jul 24.
Artigo
Inglês
| MEDLINE | ID: mdl-23602807
18.
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science
; 330(6005): 831-5, 2010 Nov 05.
Artigo
Inglês
| MEDLINE | ID: mdl-21051639
19.
Hydration changes accompanying the binding of minor groove ligands with DNA.
Biophys J
; 92(3): 959-65, 2007 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17114230