Detalhe da pesquisa
1.
Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation.
J Enzyme Inhib Med Chem
; 39(1): 2353711, 2024 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-38887057
2.
Design and Synthesis of Novel Phthalide Derivatives containing 1,3,4-Oxadiazole/1,2,4-Triazole Units as Potential Antifungal Agents.
Chem Biodivers
; 21(3): e202400043, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38361278
3.
Aerobic Dehydrogenative Aromatization in the Preparation of 4-Aminoquinoline Derivatives by Synergistic Pd/Cu Catalysis.
J Org Chem
; 88(22): 15589-15596, 2023 Nov 17.
Artigo
Inglês
| MEDLINE | ID: mdl-37931324
4.
Design, synthesis and biological evaluation of cajanonic acid A analogues as potent PPAR γ antagonists.
Bioorg Med Chem Lett
; 80: 129081, 2023 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36414176
5.
Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3Kα inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2155638, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-36650905
6.
Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies.
Bioorg Chem
; 127: 106007, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35849893
7.
Synthesis and biological evaluation of cajanonic acid A derivatives as potential PPARγ antagonists.
Bioorg Med Chem Lett
; 52: 128410, 2021 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34626784
8.
Design, synthesis and evaluation of tetrahydrocarbazole derivatives as potential hypoglycemic agents.
Bioorg Chem
; 115: 105172, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34303898
9.
Pharmacokinetics, Tissue Distribution, and Excretion Study of Cajanonic Acid A in Rats by UPLC-MS/MS.
Planta Med
; 86(5): 312-318, 2020 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-32045947
10.
Novel berberine-based derivatives with potent hypoglycemic activity.
Bioorg Med Chem Lett
; 29(23): 126709, 2019 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31629632
11.
Munronin O, a potential activator for plant resistance.
Pestic Biochem Physiol
; 146: 13-18, 2018 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-29626987
12.
Protective effects of Semiaquilegia adoxoides n-butanol extract against hydrogen peroxide-induced oxidative stress in human lens epithelial cells.
Pharm Biol
; 54(9): 1656-63, 2016 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-26974044
13.
Design, synthesis and biological evaluation of GY3-based derivatives for anti-type 2 diabetes activity.
Bioorg Med Chem Lett
; 25(7): 1500-5, 2015 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25724827
14.
Development of a hydroxypropyl methyl cellulose/polyacrylic acid interpolymer complex formulated buccal mucosa adhesive film to facilitate the delivery of insulin for diabetes treatment.
Int J Biol Macromol
; 269(Pt 2): 131876, 2024 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-38685543
15.
Integrated investigation and experimental validation of PPARG as an oncogenic driver: implications for prognostic assessment and therapeutic targeting in hepatocellular carcinoma.
Front Pharmacol
; 14: 1298341, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-38044948
16.
Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs.
Eur J Med Chem
; 260: 115754, 2023 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37651880
17.
Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors.
Eur J Med Chem
; 204: 112637, 2020 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32717477
18.
Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.
Bioorg Med Chem Lett
; 19(12): 3324-7, 2009 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19423341
19.
Oleanolic acid derivative DKS26 exerts antidiabetic and hepatoprotective effects in diabetic mice and promotes glucagon-like peptide-1 secretion and expression in intestinal cells.
Br J Pharmacol
; 174(17): 2912-2928, 2017 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-28627773