Detalhe da pesquisa
1.
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
Nat Chem Biol
; 15(11): 1057-1066, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31591564
2.
Development of an automated assay for accelerated in vitro detection of DNA adduct-inducing and crosslinking agents.
Bioorg Med Chem Lett
; 35: 127813, 2021 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33486050
3.
Mitoxantrone, More than Just Another Topoisomerase II Poison.
Med Res Rev
; 36(2): 248-99, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26286294
4.
Structure-guided design of a selective BCL-X(L) inhibitor.
Nat Chem Biol
; 9(6): 390-7, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23603658
5.
A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim.
Proc Natl Acad Sci U S A
; 106(49): 20723-7, 2009 Dec 08.
Artigo
Inglês
| MEDLINE | ID: mdl-19926852
6.
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
Cell Death Dis
; 12(3): 268, 2021 03 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33712556
7.
Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library.
Antimicrob Agents Chemother
; 54(5): 1712-9, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20160053
8.
Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity.
Bioorg Med Chem Lett
; 20(15): 4611-3, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20580556
9.
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Antimicrob Agents Chemother
; 53(7): 2824-33, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19364854
10.
A concise total synthesis of naamidine A.
Org Lett
; 8(3): 419-21, 2006 Feb 02.
Artigo
Inglês
| MEDLINE | ID: mdl-16435849
11.
Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.
J Med Chem
; 48(8): 2964-71, 2005 Apr 21.
Artigo
Inglês
| MEDLINE | ID: mdl-15828835
12.
An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus.
J Med Chem
; 46(15): 3181-4, 2003 Jul 17.
Artigo
Inglês
| MEDLINE | ID: mdl-12852746
13.
Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides.
Int J Parasitol
; 44(5): 285-9, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24583112
14.
Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
ACS Med Chem Lett
; 5(6): 662-7, 2014 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24944740
15.
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
ACS Med Chem Lett
; 5(10): 1088-93, 2014 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25313317
16.
An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.
ACS Med Chem Lett
; 3(4): 303-7, 2012 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24900468
17.
M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.
Biochem Pharmacol
; 82(11): 1604-18, 2011 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21889927
18.
New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.
J Med Chem
; 53(19): 6851-66, 2010 Oct 14.
Artigo
Inglês
| MEDLINE | ID: mdl-20860366
19.
Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza.
Angew Chem Int Ed Engl
; 42(27): 3118-21, 2003 Jul 14.
Artigo
Inglês
| MEDLINE | ID: mdl-12866095
20.
Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A.
Bioorg Med Chem Lett
; 17(13): 3741-4, 2007 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17462892