Detalhe da pesquisa
1.
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs.
Bioorg Med Chem Lett
; 21(6): 1582-7, 2011 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21349710
2.
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs.
Bioorg Med Chem Lett
; 21(6): 1588-92, 2011 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21349711
3.
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs.
Bioorg Med Chem Lett
; 20(2): 618-22, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20006499
4.
Antithrombotic potential of GW813893: a novel, orally active, active-site directed factor Xa inhibitor.
J Cardiovasc Pharmacol
; 52(1): 66-71, 2008 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-18645410
5.
Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.
Bioorg Med Chem Lett
; 18(1): 28-33, 2008 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18053714
6.
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs.
Bioorg Med Chem Lett
; 18(1): 23-7, 2008 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18054228
7.
Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.
J Med Chem
; 50(7): 1546-57, 2007 Apr 05.
Artigo
Inglês
| MEDLINE | ID: mdl-17338508
8.
Sulfonamide-related conformational effects and their importance in structure-based design.
Bioorg Med Chem Lett
; 17(10): 2931-4, 2007 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17336062
9.
Selective and dual action orally active inhibitors of thrombin and factor Xa.
Bioorg Med Chem Lett
; 17(10): 2927-30, 2007 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17420122
10.
Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors.
Bioorg Med Chem Lett
; 16(22): 5731-5, 2006 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16982192
11.
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.
Bioorg Med Chem Lett
; 16(14): 3784-8, 2006 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16697194
12.
Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.
Bioorg Med Chem Lett
; 16(23): 5953-7, 2006 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16982190