Detalhe da pesquisa
1.
Pathogenic Aß production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
J Biol Chem
; 299(8): 104997, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37394008
2.
Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy.
J Cell Biochem
; 124(7): 1040-1049, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37288821
3.
PCSK9 acts as a key regulator of Aß clearance across the blood-brain barrier.
Cell Mol Life Sci
; 79(4): 212, 2022 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-35344086
4.
Meprin ß knockout reduces brain Aß levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
Cell Mol Life Sci
; 79(3): 168, 2022 Mar 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35235058
5.
Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis.
Cell Mol Life Sci
; 79(1): 55, 2021 Dec 16.
Artigo
Inglês
| MEDLINE | ID: mdl-34913091
6.
The metalloprotease ADAMTS4 generates N-truncated Aß4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Acta Neuropathol
; 137(2): 239-257, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30426203
7.
The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM.
Brain Behav Immun
; 73: 21-33, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30041013
8.
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.
Bioorg Med Chem Lett
; 28(8): 1417-1422, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29463448
9.
Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Biochemistry
; 56(51): 6713-6725, 2017 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-29185711
10.
Low density lipoprotein receptor-related protein 1 mediated endocytosis of ß1-integrin influences cell adhesion and cell migration.
Exp Cell Res
; 340(1): 102-15, 2016 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26610862
11.
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
Bioorg Med Chem Lett
; 25(4): 841-6, 2015 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25575659
12.
Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing.
Exp Cell Res
; 319(13): 1956-1972, 2013 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23701949
13.
The metalloprotease meprin ß generates amino terminal-truncated amyloid ß peptide species.
J Biol Chem
; 287(40): 33304-13, 2012 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-22879596
14.
DOGS: reaction-driven de novo design of bioactive compounds.
PLoS Comput Biol
; 8(2): e1002380, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22359493
15.
Membrane anchoring γ-secretase modulators with terpene-derived moieties.
Bioorg Med Chem Lett
; 23(13): 3852-6, 2013 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23707256
16.
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.
Cell Mol Life Sci
; 69(8): 1353-75, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22105709
17.
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
Proc Natl Acad Sci U S A
; 107(33): 14597-602, 2010 Aug 17.
Artigo
Inglês
| MEDLINE | ID: mdl-20679249
18.
Brain Region-Specific Differences in Amyloid-ß Plaque Composition in 5XFAD Mice.
Life (Basel)
; 13(4)2023 Apr 20.
Artigo
Inglês
| MEDLINE | ID: mdl-37109582
19.
Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice.
J Alzheimers Dis
; 96(3): 1097-1113, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37980670
20.
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
J Biol Chem
; 286(46): 39794-803, 2011 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21868380