Cylindrical Vector Beam Holography without Preservation of OAM Modes.

Orbital angular momentum (OAM) multiplexed holograms have attracted a great deal of attention recently due to their physically unbounded set of orthogonal helical modes. However, preserving the OAM property in each pixel hinders fine sampling of the target image in principle and requires a fundamental filtering aperture array in the detector plane. Here, we demonstrate the concept of metasurface-based vectorial holography with cylindrical vector beams (CVBs), whose unlimited polarization orders and unique polarization distributions can be used to boost information storage capacity. Although CVBs are composed of OAM modes, the holographic images do not preserve the OAM modes in our design, enabling fine sampling of the target image in a quasi-continuous way like traditional computer-generated holograms. Moreover, the images can be directly observed by passing them through a polarizer without the need for a fundamental mode filter array. We anticipate that our method may pave the way for high-capacity holographic devices.

NLRP3 Inflammasome Activation Mediates Hepatitis E Virus-Induced Neuroinflammation.

Hepatitis E virus (HEV) is a foodborne zoonotic pathogen that is supposed to be one of the most common causes of acute viral hepatitis. However, HEV infection has been recently associated with a wide spectrum of extrahepatic manifestations, particularly neurological disorders. Previous studies have shown that HEV is able to cross the blood-brain barrier (BBB) and induce inflammatory response of the central nervous system. However, the pathogenesis of HEV-induced neuroinflammation and tissue injury of the central nervous system have yet to be fully elucidated. In this study, activation of NLRP3 inflammasome following HEV infection were investigated. In a gerbil model infected by HEV, brain histopathological changes including gliosis, neuronophagia and neuron injury were observed and expression of NLRP3, caspase-1, IL-1ß and IL-18 were elevated. Brain microvascular endothelial cells (BMECs) are key components of the BBB that protects the brain from various challenges. Following HEV infection, virus-like particles range from 30 to 40 nm in diameter were observed in human BMECs (hBMECs). Enhanced expression levels of NLRP3 and subsequent ASC, caspase-1, IL-1ß and IL-18 were detected in infected cells. Treatment with MCC950 alleviated HEV infection induced activation of NLRP3 inflammasome, mitochondrial damage and VE-cadherin degradation. The findings provide new insights into HEV-associated neuroinflammation. Moreover, targeting NLRP3 inflammasome signalling is a promising therapeutic in HEV-induced neurological disorder.

Tightly focusing metalens based on the high order Bessel function.

We propose a new, to the best of our knowledge, type of metalens of which the phase profile is extracted from the higher-order Bessel function. A light beam passing through this metalens would focus along the circular trajectory and produces a tightly focusing field. Utilizing phase binarization, we provide a method to design the geometric-phase dielectric metasurface both for phase and polarization modulations. We demonstrate two metalenses for circularly and radially polarized output beams at 633 nm, with the measured 0.737λ and 0.616λ focal spots, respectively. Theoretically, it can realize a super-diffraction-limit spot (0.38λ). This work can extend the way of realizing tightly focused optical devices.

Mathieu and Weber tightly autofocusing beams.

We theoretically investigate the propagation dynamics of vectorial Mathieu and Weber tightly autofocusing beams, which are constructed based on nonparaxial Weber and Mathieu accelerating beams, respectively. They can automatically focus along the paraboloid and ellipsoid, and the focal fields represent the tightly focusing properties resembling that generated with a high NA lens. We demonstrate the influence of the beam parameters on the spot size and energy proportion of longitudinal component of the focal fields. It reveals that Mathieu tightly autofocusing beam supports a more superior focusing performance, of which the longitudinal field component with superoscillatory feature could be enhanced by decreasing the order and selecting the suitable interfocal separation of the beam. These results are expected to provide new insights for the autofocusing beams and the tight focusing of the vector beams.

Spin-orbit coupling induced polarization transform in the autofocusing of ring Airy beams with hybrid polarizations.

Manipulating polarization is of significance for the application of light. Spin-orbit coupling provides a prominent pathway for manipulating the polarization of light field but generally requires tight focusing conditions or anisotropic media. In this paper, we construct ring Airy beams with hybrid polarizations and reveal the controllable polarization transforms in their autofocusing dynamics by manipulating concomitant spin-orbit coupling in free space. The numerical and experimental results show that the polarization transform is dependent on the azimuthal orders of amplitude and vortex phases of two spin constituents of ring Airy beams, that the focal spots present pure linear polarization whose orientation is determined by the initial phase when the vortex phase topological charge is equal to the amplitude angular factor, otherwise, the focal fields present cylindrical vector polarizations whose orders depend on the difference of amplitude angular orders and topological charges. Our work provides new insights for studying spin-orbit interactions and the depolarization of complex polarization.

Phase-type diffractive micro-optics elements in sulfur-based polymeric glass by femtosecond laser direct writing.

Sulfur-based polymeric glasses are promising alternative low-cost IR materials due to their profoundly high IR transparency. In this Letter, femtosecond-laser-induced refractive index change (RIC) was investigated in one typical sulfur-based polymeric glass material, poly(S-r-DIB), for the first time, to the best of our knowledge. The RIC in the laser-engineered region was quantitively characterized, which laid a foundation for phase-type optical element design. By the integration of RIC traces, embedded phase-type micro-optics elements, including Fresnel zone plates, and a Dammann grating were fabricated in bulk poly(S-r-DIB) polymeric glass substrate via the femtosecond laser direct writing technique. The imaging and beam shaping performance were demoed in the near-infrared (NIR) region.

Vectorial holography for independent intensity and polarization control.

Metasurface-based vectorial holography can reconstruct images with different polarization states. However, the number of polarization channels in the holographic image is relatively small in traditional methods. Here, we propose and demonstrate a metasurface vectorial hologram which carries infinite polarization channels. It can independently control the holographic pattern and polarization distribution, which can be regarded as two independent storage dimensions. We use a supercell-based metasurface to independently control the complex amplitude of the left-handed circularly polarized and right-handed circularly polarized components of the transmitted light, which then superpose in the observation plane for the vectorial pattern generation. Different from most methods, our approach does not involve complex calculations, and it is suitable for far-field design. We anticipate that it may open avenues for future applications which require arbitrary intensity and polarization control.

Biocompatible Nanotomography of Tightly Focused Light.

Tightly focusing a spatially modulated laser beam lays the foundations for advanced optical techniques, such as a holographic optical tweezer and deterministic super-resolution imaging. Precisely mapping the subwavelength features of those highly confined fields is critical to improving the spatial resolution, especially in highly scattering biotissues. However, current techniques characterizing focal fields are mostly limited to conditions such as under a vacuum and on a glass surface. An optical probe with low cytotoxicity and resistance to autofluorescence is the key to achieving in vivo applications. Here, we use a newly emerging quantum reference beacon, the nitrogen-vacancy (NV) center in the nanodiamond, to characterize the focal field of the near-infrared (NIR) laser focus in Caenorhabditis elegans (C. elegans). This biocompatible background-free focal field mapping technique has the potential to optimize in vivo optical imaging and manipulation.

Tightly autofocusing beams along the spherical surface.

We theoretically demonstrate different propagation trajectories of tightly autofocusing beams (TABs) along the spherical surface. The generalized expression of the TAB with spherical trajectory is given based on the nonparaxial accelerating Bessel beam. The effect of the spherical trajectory on the focusing performance of the TAB is analyzed. It reveals that the focal field with strong longitudinally polarized component and sub-diffraction-limit focal spot can be further enhanced by shortening the focal length of TAB. Theoretically, the minimum size of the focal spot can be close to 0.096λ2, and the proportion of longitudinal field can go up to 98.36%.

Flexible trajectory control of Bessel beams with pure phase modulation.

Spatial phase modulation has become an important method for the design of new self-accelerating light beams. Based on the transverse-longitudinal mapping of Bessel beam, we propose a method of pure phase modulation to directly convert a zero-order Bessel beam into a self-accelerating beam, of which the propagation trajectories can be flexibly predesigned. We experimentally demonstrate three typical types of curves that the modulated Bessel beam propagates along, and the parabolic, spiral, and teleporting self-accelarating beams are realized. The experimental results match the expected trajectory well. This method is simple to operate, and imposes fewer restrictions on the beam trajectory.

Poincaré sphere analogue for optical vortex knots.

We propose a Poincaré sphere (PS) analogue for optical vortex knots. The states on the PS analogue represent the light fields containing knotted vortex lines in three-dimensional space. The state changes on the latitude and longitude lines lead to the spatial rotation and scale change of the optical vortex knots, respectively. Furthermore, we experimentally generate and observe these PS analogue states. These results provide new insights for the evolution and control of singular beams, and can be further extended to polarization topology.

Metasurface-assisted multidimensional manipulation of a light wave based on spin-decoupled complex amplitude modulation.

Achieving arbitrary manipulation of the fundamental properties of a light wave with a metasurface is highly desirable and has been extensively developed in recent years. However, common approaches are typically targeted to manipulate only one dimension of light wave (amplitude, phase, or polarization), which is not quite sufficient for the acquisition of integrated multifunctional devices. Here, we propose a strategy to design single-layer dielectric metasurfaces that can achieve multidimensional modulation of a light wave. The critical point of this strategy is spin-decoupled complex amplitude modulation, which is realized by combining propagation and geometric phases with polarization-dependent interference. As proofs of concept, perfect vector vortex beams and polarization-switchable stereoscopic holographic scenes are experimentally demonstrated to exhibit the capability of multidimensional light wave manipulation, which unlocks a flexible approach for the multidimensional manipulation of a light wave such as complex light-wave control and vectorial holography in integrated optics and polarization-oriented applications.

Observation of optical vortex knots and links associated with topological charge.

Knots and links, as three-dimensional topologies, have played a fundamental role in many physical fields. Despite knotted vortex loops having been shown to exist in the light field, the three-dimensional configuration of vortex loop is fixed due to their topological robustness, making the fields with different topologies independent of each other. In this work, we established the mapping between the torus knots/links and the integer topological charge of the optical vortex, and demonstrated the change of the intermediate state with fractional charges. Furthermore, we experimentally observed the transformation process of the three-dimensional topological structure by only changing the topological charge. Remarkably, we revealed two different reconnection mechanisms associated with the odd or even index of the torus topology. We hope these results may provide new insight for the study of singular optics and evolution in other physical fields.

Liquid-crystal splitter for generating and separating autofocusing and autodefocusing circular Airy beams.

A unique splitter is proposed and demonstrated to realize the generation and separation of autofocusing and autodefocusing circular Airy beams (CABs). The design of the splitter is derived from the Fourier transform of a CAB associated with the Pancharatnam-Berry phase, and the fabrication is carried out via a liquid-crystal photo-patterning technique. Autofocusing and autodefocusing CABs of orthogonal circular polarization states are spatially diffracted under the modulation of the splitter, and the energy distribution between these two CABs can be controlled by the incident polarization. A focal length of 40 cm is obtained, which can be customized as required. The propagation dynamics of the generated autofocusing and autodefocusing CABs are investigated, and the experimental results are in good accordance with the corresponding simulations. The additional merits of the splitter, such as reconfigurability, tunability, high efficiency, and wide operating wavelength range, may motivate novel applications of CABs in the areas of laser optics, biomedicine, and modern displays.

Autofocusing of ring Airy beams embedded with off-axial vortex singularities.

We report the autofocusing behaviors of ring Airy beams (RABs) embedded with two kinds of off-axial vortex singularities. The influences of embedded positions and topological charges of point and r vortices on the autofocusing dynamic are numerically and experimentally investigated. The results show that, for the first-order vortex, the embedded position significantly affects the focal field, and once the singularity is located on the main ring of RAB, the symmetric Bessel profile of the focal field will be broken, otherwise the Bessel-like focus can self-heal at the focal plane. However, for the higher-order vortex embedded near the main ring, it will split into several fundamental vortices and then separate with each other along the radial direction under the interaction with the RAB background. Our results hold potential for the practical application of RABs in the atmosphere and other propagation systems with perturbation and even singularities.

Auto-transition of vortex- to vector-Airy beams via liquid crystal q-Airy-plates.

We propose the auto-transition of vortex-Airy to vector-Airy beams realized via a liquid crystal q-Airy-plate, whose director distribution is the integration of a q-plate and a polarization Airy mask. The polarization, phase, intensity distributions of the vortex-vector-Airy beams (VVABs) during the transition process and individual trajectories of the vortex beam, vector beam and Airy beam components are both theoretically and experimentally investigated. Interesting findings show that the pair of vortex components firstly experience transverse deflection with a smaller acceleration than the Airy components and then automatically evolve into a vector component propagating in a straight path. The polarization mode of the VVABs can be easily switched by tuning the incident polarization direction. Meanwhile, the Airy component still maintains its intrinsic self-accelerating and self-healing properties. The asymmetric intensity distribution and variation of VVABs are revealed, and the energy flows are simulated to better illustrate the interaction of the Airy, vortex and vector components. This work provides an approach for the manipulation of the spatially structured light beams, which may inspire their potential applications in optics, photonics and multidisciplinary fields.

Accurate and rapid measurement of optical vortex links and knots.

Optical vortices can evolve in light fields, of which the singularity evolution forms dark lines with complex topological structures, knotted or linked. We propose a method to more accurately and rapidly measure the topology of optical vortex fields. To accurately locate the phase singular points, phase measurement based on digital holography and, further, a numerical search algorithm, are utilized. A motor-driven right-angle prism enables the implementation of a single exposure of hologram for each measurement along the propagation direction, greatly improving the measurement speed. The three-dimensional (3D) spatial distributions of several typical vortex links and knots are experimentally reconstructed. The proposed method is expected to rapidly observe the 3D evolution of other complicated, or even vector, fields.

Helicity-dependent forked vortex lens based on photo-patterned liquid crystals.

A liquid crystal forked vortex lens integrated with Pancharatnam-Berry phase is proposed and demonstrated via a dynamic photo-patterning technique. The forked vortex lens can generate two optical vortices with opposite spin and orbital angular momentum, which are spatially separated to two focal points with one optical vortex focused and the other defocused. It exhibits distinctive helicity-dependency and ultra-high diffraction efficiency up to 95%. The topological charges of generated optical vortices are detected via astigmatic transformation. This work supplies an easy fabrication and low power consumption strategy for generating and separating (de-)focused optical vortices simultaneously.

Simulation and optimization of liquid crystal gratings with alternate twisted nematic and planar aligned regions.

Electro-optical properties of liquid crystal (LC) gratings with alternate twisted nematic (TN) and planar aligned (PA) regions are simulated. Three typical steps are introduced: first, the LC director distributions of the two different regions are simulated. Then, the phase and amplitude of the emergent light in each region are calculated through Jones matrix. Based on this information, the voltage-dependent diffraction efficiency is achieved by Fourier transformation, finally. It gives an exact explanation for the mechanism of this kind of gratings. Experiments with optimized parameters are carried out through photopatterning. The trend of the measured voltage-dependent efficiency fits the simulation result very well. This method can be used to optimize the performance of LC gratings with alternate TN and PA regions, and exhibits great potential in the simulation of corresponding photonics and display applications.

Effect of oral administration of pregabalin on physiological and echocardiographic variables in healthy cats.

OBJECTIVES: The aim of this study was to evaluate the efficacy of a single dose of oral pregabalin (PGB) for sedation and its impact on physiological and echocardiographic variables in healthy cats. METHODS: This study was a randomised, blinded, crossover trial. Eight cats were randomly assigned to receive PGB or placebo, with a 1-week washout period between each administration. Cats in the treatment group received oral PGB at varying doses (low dose: 2.5 mg/kg, medium dose: 5 mg/kg, high dose: 10 mg/kg). Systolic blood pressure (SBP), pulse rate (PR), respiratory rate (RR) and sedation score were measured at intervals of 30 mins after administration. Echocardiography was performed 120 mins after administration. RESULTS: Oral administration of PGB 2.5 mg/kg and 5 mg/kg significantly increased sedation scores starting at 150 mins, while 10 mg/kg PGB showed a significant increase in sedation scores starting at 120 mins compared with placebo. PGB 5 mg/kg and 10 mg/kg resulted in a significant reduction in SBP compared with placebo, with minimal impact on PR and RR. In addition, PGB 10 mg/kg resulted in significant changes in the peak velocity of late diastolic transmitral flow (A) and the ratio of peak velocity of early diastolic transmitral flow and A; however, these changes were of marginal clinical significance. CONCLUSIONS AND RELEVANCE: A single dose of oral PGB could cause mild to moderate sedation. Hypotension was more prevalent in the PGB 5 mg/kg and 10 mg/kg groups among the majority of cats, but it was less frequently observed in the PGB 2.5 mg/kg group.