Detalhe da pesquisa
1.
Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications.
Bioorg Med Chem Lett
; 92: 129405, 2023 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37414346
2.
Common variation of the NSD1 gene is associated with susceptibility to Hirschsprung's disease in Chinese Han population.
Pediatr Res
; 89(3): 694-700, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32380506
3.
Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents.
Bioorg Med Chem Lett
; 28(3): 293-297, 2018 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29292223
4.
Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents.
Bioorg Med Chem Lett
; 26(3): 757-760, 2016 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26778255
5.
Identification of orally-bioavailable antagonists of the TRPV4 ion-channel.
Bioorg Med Chem Lett
; 25(18): 4011-5, 2015 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26235950
6.
Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility.
Aging (Albany NY)
; 12(8): 7163-7182, 2020 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32315284
7.
Association of Variants in PLD1, 3p24.1, and 10q11.21 Regions With Hirschsprung's Disease in Han Chinese Population.
Front Genet
; 11: 738, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32765588
8.
18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons.
J Nucl Med
; 50(8): 1349-55, 2009 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-19652217
9.
Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis.
Cancer Res
; 65(9): 3950-7, 2005 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15867396
10.
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.
J Med Chem
; 48(6): 1721-4, 2005 Mar 24.
Artigo
Inglês
| MEDLINE | ID: mdl-15771418
11.
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues.
J Med Chem
; 46(6): 921-4, 2003 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-12620069
12.
New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.
J Med Chem
; 46(19): 4196-204, 2003 Sep 11.
Artigo
Inglês
| MEDLINE | ID: mdl-12954072
13.
Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy- 8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators.
Org Lett
; 4(13): 2169-72, 2002 Jun 27.
Artigo
Inglês
| MEDLINE | ID: mdl-12074659
14.
Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them.
Mol Pharmacol
; 70(4): 1454-60, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16857741
15.
A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta.
J Org Chem
; 68(23): 9116-8, 2003 Nov 14.
Artigo
Inglês
| MEDLINE | ID: mdl-14604391
16.
Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues.
Org Biomol Chem
; 1(22): 3878-81, 2003 Nov 21.
Artigo
Inglês
| MEDLINE | ID: mdl-14664377
17.
Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors.
Bioorg Med Chem Lett
; 14(8): 1855-8, 2004 Apr 19.
Artigo
Inglês
| MEDLINE | ID: mdl-15050615
18.
Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation.
J Am Chem Soc
; 126(51): 16714-5, 2004 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-15612696
19.
Acetylenic pyridines for use in PET imaging of nicotinic receptors.
ChemMedChem
; 2(1): 54-7, 2007 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-17096450