Detalhe da pesquisa
1.
Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.
Bioorg Med Chem Lett
; 27(11): 2479-2483, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28427812
2.
Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core.
Bioorg Med Chem Lett
; 27(18): 4274-4279, 2017 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28866269
3.
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.
Bioorg Med Chem Lett
; 27(22): 4999-5001, 2017 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29037946
4.
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists.
Bioorg Med Chem Lett
; 27(15): 3576-3581, 2017 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28633897
5.
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.
Bioorg Med Chem Lett
; 27(13): 2990-2995, 2017 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28522253
6.
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.
Bioorg Med Chem Lett
; 27(2): 171-175, 2017 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27939174
7.
Patient and Caregiver Perceptions of Airway Clearance Methods Used for Cystic Fibrosis.
Can Respir J
; 2023: 1422319, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37547298
8.
RNASE6 is a novel modifier of APOE-ε4 effects on cognition.
Neurobiol Aging
; 118: 66-76, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35896049
9.
Protective genes and pathways in Alzheimer's disease: moving towards precision interventions.
Mol Neurodegener
; 16(1): 29, 2021 04 29.
Artigo
Inglês
| MEDLINE | ID: mdl-33926499
10.
Inactivation of CFTR by CRISPR/Cas9 alters transcriptional regulation of inflammatory pathways and other networks.
J Cyst Fibros
; 19(1): 34-39, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31126900
11.
A new vision: Integration of ophthalmology services into an interdisciplinary pediatric cystic fibrosis clinic model.
Pediatr Pulmonol
; 59(5): 1502-1504, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38353399
12.
Ccl5 Mediates Proper Wiring of Feedforward and Lateral Inhibition Pathways in the Inner Retina.
Front Neurosci
; 12: 702, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30369865
13.
Elevation of sweat chloride levels in a patient with CFTR-related metabolic syndrome receiving dexmethylphenidate and guanfacine.
Pediatr Pulmonol
; 57(9): 2264-2266, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35570399
14.
Pretreatment with Human Chorionic Gonadotropin Protects the Neonatal Brain against the Effects of Hypoxic-Ischemic Injury.
Front Pediatr
; 5: 232, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-29164084
15.
Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core.
ACS Med Chem Lett
; 8(9): 919-924, 2017 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28947937
16.
Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs.
ACS Med Chem Lett
; 8(9): 925-930, 2017 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28947938
17.
Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia.
ACS Med Chem Lett
; 8(2): 233-238, 2017 Feb 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28197318