Detalhe da pesquisa
1.
Inclusion of maintenance energy improves the intracellular flux predictions of CHO.
PLoS Comput Biol
; 17(6): e1009022, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34115746
2.
Systematic use of synthetic 5'-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories.
Nucleic Acids Res
; 48(20): e119, 2020 11 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33051690
3.
Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities.
Biotechnol Bioeng
; 117(11): 3435-3447, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32662873
4.
A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells.
Metab Eng
; 48: 72-81, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29852271
5.
How to train your cell - Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines.
Biotechnol Adv
; 56: 107924, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35149147
6.
Subcloning induces changes in the DNA-methylation pattern of outgrowing Chinese hamster ovary cell colonies.
Biotechnol J
; 16(6): e2000350, 2021 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-33484505
7.
Directed evolution approach to enhance efficiency and speed of outgrowth during single cell subcloning of Chinese Hamster Ovary cells.
Comput Struct Biotechnol J
; 18: 1320-1329, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32612755
8.
A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets.
Sci Rep
; 9(1): 8689, 2019 06 18.
Artigo
Inglês
| MEDLINE | ID: mdl-31213643