Detalhe da pesquisa
1.
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.
J Proteome Res
; 22(10): 3159-3177, 2023 10 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37634194
2.
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.
EMBO J
; 38(20): e101443, 2019 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31424118
3.
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.
Mol Ther
; 30(1): 485-500, 2022 01 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34450249
4.
NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.
Breast Cancer Res Treat
; 189(1): 49-61, 2021 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-34196902
5.
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat Chem Biol
; 15(8): 822-829, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31285596
6.
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
Int J Mol Sci
; 22(2)2021 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33429995
7.
A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways.
Anticancer Drugs
; 31(8): 759-775, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32796402
8.
New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K).
Molecules
; 25(7)2020 Apr 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32272798
9.
In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.
Molecules
; 25(2)2020 Jan 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31941153
10.
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors.
Biochem J
; 475(15): 2435-2455, 2018 08 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29934490
11.
New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.
Biochem J
; 475(15): 2417-2433, 2018 08 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29934491
12.
Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).
Molecules
; 24(22)2019 Nov 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31698822
13.
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group.
Nat Chem Biol
; 9(5): 319-25, 2013 May.
Artigo
Inglês
| MEDLINE | ID: mdl-23524983
14.
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships.
Eur J Med Chem
; 271: 116357, 2024 May 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38636130
15.
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
bioRxiv
; 2024 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38798634
16.
Developing a Kinase Chemogenomic Set: Facilitating Investigation into Kinase Biology by Linking Phenotypes to Targets.
Methods Mol Biol
; 2706: 11-24, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37558938
17.
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.
ACS Med Chem Lett
; 14(4): 432-441, 2023 Apr 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37077385
18.
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships.
bioRxiv
; 2023 Dec 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38234837
19.
A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective.
bioRxiv
; 2023 Feb 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36798313
20.
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.
ACS Chem Neurosci
; 14(9): 1672-1685, 2023 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37084253