Detalhe da pesquisa
1.
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
EMBO J
; 39(20): e104862, 2020 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32853409
2.
Identification of LRRK2 missense variants in the accelerating medicines partnership Parkinson's disease cohort.
Hum Mol Genet
; 30(6): 454-466, 2021 04 30.
Artigo
Inglês
| MEDLINE | ID: mdl-33640967
3.
The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease.
Biochem Soc Trans
; 51(2): 747-758, 2023 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37013975
4.
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Proc Natl Acad Sci U S A
; 117(29): 17296-17307, 2020 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32631998
5.
Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease.
Mov Disord
; 37(7): 1454-1464, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35521944
6.
Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.
Acta Neuropathol
; 141(4): 547-564, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33641009
7.
Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites.
Acta Neuropathol
; 141(5): 725-754, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33694021
8.
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
Hum Mol Genet
; 27(2): 385-395, 2018 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29177506
9.
A Competency-Guided Veterinary Curriculum Review Process.
J Vet Med Educ
; 47(2): 137-147, 2020 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-31194636
10.
Veterinary Educator Teaching and Scholarship (VETS): A Case Study of a Multi-Institutional Faculty Development Program to Advance Teaching and Learning.
J Vet Med Educ
; 47(5): 632-646, 2020 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-32530798
11.
Virtual Microscopy Is More Effective Than Conventional Microscopy for Teaching Cytology to Veterinary Students: A Randomized Controlled Trial.
J Vet Med Educ
; 47(4): 475-481, 2020 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-32105198
12.
The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease.
Eur J Neurosci
; 49(3): 339-363, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30269383
13.
Caught in the act: LRRK2 in exosomes.
Biochem Soc Trans
; 47(2): 663-670, 2019 04 30.
Artigo
Inglês
| MEDLINE | ID: mdl-30837321
14.
Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).
J Biol Chem
; 292(26): 11091-11108, 2017 06 30.
Artigo
Inglês
| MEDLINE | ID: mdl-28487361
15.
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
Hum Mol Genet
; 25(1): 109-22, 2016 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26546614
16.
LRRK2-Targeting Therapies March Through the Valley of Death.
Mov Disord
; 38(3): 361-365, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36942368
17.
Identification of Novel α-Synuclein Assemblies in Lewy Body Disease.
Mov Disord
; 38(1): 21-22, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36374937
18.
G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.
J Neurosci
; 36(28): 7415-27, 2016 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-27413152
19.
The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.
Hum Mol Genet
; 24(15): 4250-67, 2015 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25926623
20.
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Hum Mol Genet
; 24(14): 4078-93, 2015 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25904107